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Monitoring treatment of Taenia solium- neurocysticercosis by detection of circulating antigens: a case report

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Show simple item record Rodriguez-Hidalgo, R. en_US Carpio, A. en_US Van den Enden, E. en_US Benitez-Ortiz, W. en_US 2019-06-04T12:10:21Z 2019-06-04T12:10:21Z 2019 en_US
dc.identifier.issn 1471-2377 en_US
dc.identifier.doi en_US
dc.identifier.other en_US
dc.identifier.other 5 pp. en_US
dc.identifier.other 20 en_US
dc.identifier.other ITG-C3X; DCS; U-xxx; JIF; DOI; PDF; PMC; Abstract; ITMPUB; DSPACE67 en_US
dc.description.abstract BACKGROUND: Parenchymal neurocysticercosis is a frequent cause of seizures in areas endemic for Taenia solium. At present there is scarce data on the evolution of the levels of circulating metacestodal antigen before, during and after treatment with anthelmintic drugs. CASE PRESENTATION: A patient with paucisymptomatic neurocysticercosis (NCC) diagnosed by Ag-ELISA, and confirmed by MRI images, was treated with praziquantel, albendazole and dexamethasone. The level of circulating T. solium antigen was determined weekly. Circulating antigen disappeared from his blood within 14 days after the start of the treatment and correlated with the involution of the cysticerci in the brain shown by imaging. Seventeen years later, the patient has not shown any side effect nor symptoms related to the treatment or to NCC. CONCLUSIONS: If this encouraging finding is confirmed in a larger series of patients, this technique could be used to determine parasitological cure after treatment and might complement or sometimes replace sequential MRI-imaging of the brain. en_US
dc.language English en_US
dc.relation.uri en_US
dc.subject Neurocysticercosis en_US
dc.subject Helminthic diseases en_US
dc.subject Taenia solium en_US
dc.subject Neurological disorders en_US
dc.subject Treatment en_US
dc.title Monitoring treatment of Taenia solium- neurocysticercosis by detection of circulating antigens: a case report en_US
dc.type Article-E en_US
dc.citation.issue 1 en_US
dc.citation.jtitle BMC Neurology en_US
dc.citation.volume 19 en_US
dc.citation.pages 52 en_US
dc.citation.abbreviation BMC Neurol en_US

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