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A comparative immunogenicity and safety trial of two different schedules of single-visit intradermal rabies post-exposure vaccination following a single-visit pre-exposure vaccination [Epub ahead of print]

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dc.contributor.author Soentjens, P. en_US
dc.contributor.author De Koninck, K. en_US
dc.contributor.author Tsoumanis, A. en_US
dc.contributor.author Herssens, N. en_US
dc.contributor.author Van den Bossche, D. en_US
dc.contributor.author Terryn, S. en_US
dc.contributor.author Van Gucht, S. en_US
dc.contributor.author Van Damme, P. en_US
dc.contributor.author Van Herrewege, Y. en_US
dc.contributor.author Bottieau, E. en_US
dc.date.accessioned 2019-06-04T12:11:17Z
dc.date.available 2019-06-04T12:11:17Z
dc.date.issued 2018 en_US
dc.identifier.issn 1058-4838 en_US
dc.identifier.doi http://dx.doi.org/10.1093/cid/ciy983 en_US
dc.identifier.other http://lib.itg.be/pdf/itg/2018/2018cidi0001.pdf en_US
dc.identifier.other 7 pp. en_US
dc.identifier.other 30 en_US
dc.identifier.other ITG-C1A; ITG-C3A; ITG-C4A; ITG-C5A; ITG-C9A; ITG-CLA; DCS; U-TRAVM; U-CTU; U-CLCB; U-TROPIC; JIF; DOI; PDF; Abstract; ITMPUB; DSPACE66 en_US
dc.identifier.uri http://hdl.handle.net/10390/10339
dc.description.abstract BACKGROUND: Effective and safe single-visit rabies vaccination for pre- and post-exposure prophylaxis (PrEP and PEP) could substantially simplify rabies prevention and therefore increase compliance. METHODS: In a comparative trial, 303 healthy adults received a primary vaccination consisting of two intradermal (ID) doses of 0.1mL of the purified chicken embryo cell vaccine (PCEV) during a single visit. One year later, subjects were randomly assigned to receive either four or two ID PEP booster doses of 0.1mL of PCEV during a single visit. The primary endpoint for immunogenicity was the percentage of subjects with an adequate antibody level (>0.5 IU/mL) seven days after the booster doses. The safety endpoint was the proportion of participants developing adverse events (AE) following primary and/or booster vaccination. RESULTS: ll subjects, except one (99.3%) in each study group, had a rabies antibody titer >0.5 IU/mL on day 7 following the booster schedules. Subjects exposed to the four-dose PEP schedule had a geometric mean titer of 20 IU/mL versus 14 IU/mL for the two-dose PEP schedule (p=0.0228). Local reactions at the injection site following PrEP and PEP were mild and transient and only seen in 14.9% and 49.6 to 53% of the participants respectively. No serious AE were reported. CONCLUSION: In healthy adults, a two-dose (2x 0.1mL) single-visit intradermal post-exposure prophylaxis schedule was as immunologically adequate and safe as a four-dose (4x 0.1mL) single-visit PEP schedule, seven to twenty-eight months following a two-dose (2x 0.1mL) single-visit intradermal pre-exposure prophylaxis. en_US
dc.language English en_US
dc.relation.uri http://www.ncbi.nlm.nih.gov/pubmed/30566636 en_US
dc.subject Rabies en_US
dc.subject Viral diseases en_US
dc.subject Prevention en_US
dc.subject Vaccination en_US
dc.title A comparative immunogenicity and safety trial of two different schedules of single-visit intradermal rabies post-exposure vaccination following a single-visit pre-exposure vaccination [Epub ahead of print] en_US
dc.type Article-P en_US
dc.citation.jtitle Clinical Infectious Diseases en_US
dc.citation.abbreviation Clin Infect Dis en_US


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