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Predominance of HIV type 1 subtype G among commercial sex workers from Kinshasa, Democratic Republic of Congo

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Show simple item record Yang, C. en_US Dash, B. en_US Hanna, S. L. en_US Frances, H. S. en_US Nzilambi, N. en_US Colebunders, R. L. en_US St. Louis, M. en_US Quinn, T. C. en_US Folks, T. M. en_US Lal, R. B. en_US 2007-12-06T14:39:31Z 2007-12-06T14:39:31Z 2001 en_US
dc.identifier.issn 0889-2229 en_US
dc.identifier.other JIF en_US
dc.identifier.other ITG-C6A en_US
dc.identifier.other CLINIC en_US
dc.identifier.other U-HIVCLI en_US
dc.identifier.other DOI en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.other FTA
dc.description.abstract We have investigated the genetic diversity and potential mosaic genomes of HIV-1 during the early part of the HIV-1 epidemic among commercial sex workers (CSWs) in Kinshasa, Democratic Republic of Congo (formerly Zaire). Serologic analysis revealed that 27 (28.7%) of the 94 specimens were seropositive by both peptide and whole-virus lysate EIAs and that 24 were positive by molecular screening assays, using generic primers that can detect all known groups of HIV-1. Phylogenetic analyses of the gag(p24), C2V3, and gp41 regions of these 24 specimens showed that all were group M; none of them had any evidence of group O, N, or SIVcpz-like sequences. On the basis of env sequence analysis, the 24 group M specimens were classified as subtypes G (37.5%), A (21%), F1 (12.5%), CRF01_AE (8%), D (4%), and H (4%); 3 (12.5%) were unclassifiable (U). Similar analysis of the gag(p24) region revealed that the majority of infections were subtype A; however, one-third of the specimens were subtype G. Parallel analysis of gag(p24) and env regions revealed discordant subtypes in many specimens that may reflect possible dual and/or recombinant viruses. These data suggest a predominance of subtype G (both pure G and recombinant CRF02_AG) during the early part of the epidemic in Kinshasa. Infections with group N or SIVcpz-like viruses were not present among these CSWs in Kinshasa. en_US
dc.language English en_US
dc.subject Viral diseases en_US
dc.subject HIV-1 en_US
dc.subject Subtype G en_US
dc.subject Diversity en_US
dc.subject Genetic variation en_US
dc.subject Prostitutes en_US
dc.subject Kinshasa en_US
dc.subject Congo-Kinshasa en_US
dc.subject Africa, Central en_US
dc.title Predominance of HIV type 1 subtype G among commercial sex workers from Kinshasa, Democratic Republic of Congo en_US
dc.type Article en_US
dc.citation.issue 4 en_US
dc.citation.jtitle AIDS Research and Human Retroviruses en_US
dc.citation.volume 17 en_US
dc.citation.pages 361-365 en_US
dc.citation.jabbreviation AIDS Res Hum Retroviruses en_US

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