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Superimposing incident sexually transmitted infections on HIV phylogram to investigate possible misclassification of men who have sex with men as heterosexuals in a cohort in Antwerp, Belgium

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dc.contributor.author Osbak, K. K. en_US
dc.contributor.author Meehan, C. J. en_US
dc.contributor.author Ribas, G. en_US
dc.contributor.author Heyndrickx, L. en_US
dc.contributor.author Ariën, K. K. en_US
dc.contributor.author Tsoumanis, A. en_US
dc.contributor.author Florence, E. en_US
dc.contributor.author Esbroeck, M. V. en_US
dc.contributor.author Fransen, K. en_US
dc.contributor.author Kenyon, C. R. en_US
dc.date.accessioned 2019-06-04T12:20:43Z
dc.date.available 2019-06-04T12:20:43Z
dc.date.issued 2019 en_US
dc.identifier.issn 0956-4624 en_US
dc.identifier.doi http://dx.doi.org/10.1177/0956462418821752 en_US
dc.identifier.other ITG-C1A; ITG-BxA; ITG-CxA; ITG-CLA; MULTI; DPH; U-STINF; U-CTU; U-STDCLI; U-CLCB; U-ARLAB; DBM; U-MYCOB; U-VIROL; JIF; DOI; CPDF; Abstract; ITMPUB; DSPACE67 en_US
dc.identifier.uri http://hdl.handle.net/10390/10633
dc.description.abstract In this study, we assessed if the superimposition of incident sexually transmitted infections (STIs) on HIV phylogenetic analyses could reveal possible sexual behaviour misclassifications in our HIV-infected population. HIV-1 sequences collected between 1997 and 2014 from 1169 individuals attending a HIV clinic in Antwerp, Belgium were analysed to infer a partial HIV transmission network. Individual demographic, clinical and laboratory data collected during routine HIV follow-up were used to compare clustered and non-clustered individuals using logistic regression analyses. In total, 438 (37.5%) individuals were identified in 136 clusters, including 76 transmission pairs and 60 clusters consisting of three or more individuals. Individuals in a cluster were more likely to have a history of syphilis, Chlamydia and/or gonorrhoea (P < 0.05); however, when analyses were stratified by HIV transmission risk groups (heterosexual and men who have sex with men [MSM]), this association only remained significant for heterosexuals with syphilis (P = 0.001). Under closer scrutiny, this association was driven by six heterosexual men who were located in six almost exclusively MSM clusters. A parsimonious conclusion is that these six individuals were potentially misclassified as heterosexual. Improving the accuracy of sexual behaviour reporting could improve care. en_US
dc.language English en_US
dc.relation.uri http://www.ncbi.nlm.nih.gov/pubmed/30999835 en_US
dc.subject HIV en_US
dc.subject Viral diseases en_US
dc.subject Sexually transmitted diseases en_US
dc.subject STD en_US
dc.subject Homosexuals en_US
dc.subject Belgium en_US
dc.subject Europe-West en_US
dc.title Superimposing incident sexually transmitted infections on HIV phylogram to investigate possible misclassification of men who have sex with men as heterosexuals in a cohort in Antwerp, Belgium en_US
dc.type Article en_US
dc.citation.issue 5 en_US
dc.citation.jtitle International Journal of STD & AIDS en_US
dc.citation.volume 30 en_US
dc.citation.pages 486-495 en_US
dc.citation.abbreviation Int J STD AIDS en_US


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