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Sero-epidemiological status and risk factors of toxoplasmosis in pregnant women in Northern Vietnam

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dc.contributor.author Smit, G. S. A. en_US
dc.contributor.author Vu, B. T. L. en_US
dc.contributor.author Do, D. T. en_US
dc.contributor.author Do, Q. H. en_US
dc.contributor.author Pham, H. Q. en_US
dc.contributor.author Speybroeck, N. en_US
dc.contributor.author Devleesschauwer, B. en_US
dc.contributor.author Padalko, E. en_US
dc.contributor.author Roets, E. en_US
dc.contributor.author Dorny, P. en_US
dc.date.accessioned 2019-06-04T12:20:47Z
dc.date.available 2019-06-04T12:20:47Z
dc.date.issued 2019 en_US
dc.identifier.issn 1471-2334 en_US
dc.identifier.doi http://dx.doi.org/10.1186/s12879-019-3885-7 en_US
dc.identifier.other http://lib.itg.be/pdf/itg/2019/2019bidi0329.pdf en_US
dc.identifier.other 8 pp. en_US
dc.identifier.other 37 en_US
dc.identifier.other ITG-BLA; DBM; U-VHELM; JIF; DOI; PDF; PMC; Abstract; ITMPUB; DSPACE67 en_US
dc.identifier.uri http://hdl.handle.net/10390/10641
dc.description.abstract BACKGROUND: In Vietnam, few studies have determined the epidemiological status of toxoplasmosis in pregnant women and no routine prenatal screening is in place. This study was conducted to evaluate the seroprevalence of this zoonotic parasitic infection in pregnant women in Northern Vietnam and to assess the association with awareness, risk factors and congenital toxoplasmosis. METHODS: Approximately 800 pregnant women were included in the study from two hospitals, one in Hanoi and one in Thai Binh province, which is known to have a dense cat population. Serological immunoglobulin G (IgG) and immunoglobulin M (IgM) detection was performed to estimate the seroprevalence of toxoplasmosis and sero-incidence of maternal and congenital toxoplasmosis. In addition, a survey was conducted about awareness, clinical history, presentation of signs and symptoms relating to toxoplasmosis and to detect biologically plausible and socio-demographic risk factors associated with toxoplasmosis. Associations with seroprevalence were assessed using univariable and multivariable analysis. RESULTS: The mean IgG seroprevalence after the full diagnostic process was 4.5% (95% confidence interval(CI): 2.7-7.0) and 5.8% (95% CI: 3.7-8.6) in Hanoi and Thai Binh hospital, respectively, and included one seroconversion diagnosed in Thai Binh hospital. Only 2.0% of the pregnant women in Hanoi hospital and 3.3% in Thai Binh hospital had heard about toxoplasmosis before this study. CONCLUSION: Since the percentage of seronegative, and thus susceptible, pregnant women was high and the awareness was low, we suggest to distribute information about toxoplasmosis and its prevention among women of child bearing age. Furthermore, future studies are recommended to investigate why such a low seroprevalence was seen in pregnant women in Northern Vietnam compared to other countries in South East Asia and globally. en_US
dc.language English en_US
dc.relation.uri http://www.ncbi.nlm.nih.gov/pubmed/30999869 en_US
dc.subject Toxoplasmosis en_US
dc.subject Protozoal diseases en_US
dc.subject Pregnancy en_US
dc.subject Risk factors en_US
dc.subject Vietnam en_US
dc.subject Asia-East en_US
dc.title Sero-epidemiological status and risk factors of toxoplasmosis in pregnant women in Northern Vietnam en_US
dc.type Article-E en_US
dc.citation.issue 1 en_US
dc.citation.jtitle BMC Infectious Diseases en_US
dc.citation.volume 19 en_US
dc.citation.pages 329 en_US
dc.citation.abbreviation BMC Infect Dis en_US


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