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A cross-sectional study of tuberculosis drug resistance among previously treated patients in a tertiary hospital in Accra, Ghana: public health implications of standardized regimens

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dc.contributor.author Forson, A. en_US
dc.contributor.author Kwara, A. en_US
dc.contributor.author Kudzawu, S. en_US
dc.contributor.author Omari, M. en_US
dc.contributor.author Otu, J. en_US
dc.contributor.author Gehre, F. en_US
dc.contributor.author De Jong, B. en_US
dc.contributor.author Antonio, M. en_US
dc.date.accessioned 2019-06-04T12:21:23Z
dc.date.available 2019-06-04T12:21:23Z
dc.date.issued 2018 en_US
dc.identifier.issn 1471-2334 en_US
dc.identifier.doi http://dx.doi.org/10.1186/s12879-018-3053-5 en_US
dc.identifier.other http://lib.itg.be/pdf/itg/2018/2018bidi0149.pdf en_US
dc.identifier.other 6 pp. en_US
dc.identifier.other 19 en_US
dc.identifier.other ITG-B6A; ITG-B7A; DBM; U-MYCOB; JIF; DOI; PDF; OAJ; E-only; Abstract; ITMPUB; DSPACE65 en_US
dc.identifier.uri http://hdl.handle.net/10390/10698
dc.description.abstract BACKGROUND: Mycobacterium tuberculosis drug resistance is a major challenge to the use of standardized regimens for tuberculosis (TB) therapy, especially among previously treated patients. We aimed to investigate the frequency and pattern of drug resistance among previously treated patients with smear-positive pulmonary tuberculosis at the Korle-Bu Teaching Hospital Chest Clinic, Accra. METHODS: This was a cross-sectional survey of mycobacterial isolates from previously treated patients referred to the Chest Clinic Laboratory between October 2010 and October 2013. The Bactec MGIT 960 system for mycobactrerial culture and drug sensitivity testing (DST) was used for sputum culture of AFB smear-positive patients with relapse, treatment failure, failure of smear conversion, or default. Descriptive statistics were used to summarize patient characteristics, and frequency and patterns of drug resistance. RESULTS: A total of 112 isolates were studied out of 155 from previously treated patients. Twenty contaminated (12.9%) and 23 non-viable isolates (14.8%) were excluded. Of the 112 studied isolates, 53 (47.3%) were pan-sensitive to all first-line drugs tested Any resistance (mono and poly resistance) to isoniazid was found in 44 isolates (39.3%) and any resistance to streptomycin in 43 (38.4%). Thirty-one (27.7%) were MDR-TB. Eleven (35.5%) out of 31 MDR-TB isolates were pre-XDR. MDR-TB isolates were more likely than non-MDR isolates to have streptomycin and ethambutol resistance. CONCLUSIONS: The main findings of this study were the high prevalence of MDR-TB and streptomycin resistance among previously treated TB patients, as well as a high prevalence of pre-XDR-TB among the MDR-TB patients, which suggest that first-line and second-line DST is essential to aid the design of effective regimens for these groups of patients in Ghana. en_US
dc.language English en_US
dc.relation.uri http://www.ncbi.nlm.nih.gov/pubmed/29606091 en_US
dc.subject Tuberculosis-multidrug-resistant en_US
dc.subject Public health en_US
dc.subject Hospitals en_US
dc.subject Ghana en_US
dc.subject Africa-North en_US
dc.title A cross-sectional study of tuberculosis drug resistance among previously treated patients in a tertiary hospital in Accra, Ghana: public health implications of standardized regimens en_US
dc.type Article-E en_US
dc.citation.issue 1 en_US
dc.citation.jtitle BMC Infectious Diseases en_US
dc.citation.volume 18 en_US
dc.citation.pages 149 en_US
dc.citation.abbreviation BMC Infect Dis en_US


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