Institute of Tropical Medicine Antwerp
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Pork as a source of transmission of Toxoplasma gondii to humans: a parasite burden study in pig tissues after infection with different strains of Toxoplasma gondii as a function of time and different parasite stages

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dc.contributor.author Gisbert Algaba, I. en_US
dc.contributor.author Verhaegen, B. en_US
dc.contributor.author Jennes, M. en_US
dc.contributor.author Rahman, M. en_US
dc.contributor.author Coucke, W. en_US
dc.contributor.author Cox, E. en_US
dc.contributor.author Dorny, P. en_US
dc.contributor.author Dierick, K. en_US
dc.contributor.author De Craeye, S. en_US
dc.date.accessioned 2019-06-04T12:21:26Z
dc.date.available 2019-06-04T12:21:26Z
dc.date.issued 2018 en_US
dc.identifier.issn 0020-7519 en_US
dc.identifier.doi http://dx.doi.org/10.1016/j.ijpara.2017.12.009 en_US
dc.identifier.other http://lib.itg.be/pdf/itg/2018/2018ijpa0001.pdf en_US
dc.identifier.other 20 en_US
dc.identifier.other ITG-B7A; DBM; U-VHELM; JIF; DOI; PDF; Abstract; ITMPUB; DSPACE65 en_US
dc.identifier.uri http://hdl.handle.net/10390/10702
dc.description.abstract Toxoplasma gondii is an ubiquitous apicomplexan parasite which can infect any warm-blooded animal including humans. Humans and carnivores/omnivores can also become infected by consumption of raw or undercooked infected meat containing muscle cysts. This route of transmission is considered to account for at least 30% of human toxoplasmosis cases. To better assess the role of pork as a source of infection for humans, the parasite burden resulting from experimental infection with different parasite stages and different strains of T. gondii during the acute and chronic phases was studied. The parasite burden in different tissues was measured with a ISO 17025 validated Magnetic Capture-quantitative PCR. A high burden of infection was found in heart and lungs during the acute phase of infection and heart and brain were identified as the most parasitised tissues during the chronic phase of infection, independent of the parasite stage and the strain used. Remarkably, a higher parasite burden was measured in different tissues following infection with oocysts of a type II strain compared with a tissue cyst infection with three strains of either type II or a type I/II. However, these results could have been affected by the use of different strains and euthanasia time points. The parasite burden resulting from a tissue cyst infection was not significantly different between the two strains. en_US
dc.language English en_US
dc.relation.uri http://www.ncbi.nlm.nih.gov/pubmed/29625125 en_US
dc.subject Toxoplasmosis en_US
dc.subject Protozoal diseases en_US
dc.subject Toxoplasma gondii en_US
dc.subject Animal diseases en_US
dc.subject Zoonoses en_US
dc.subject Transmission en_US
dc.subject Pigs en_US
dc.title Pork as a source of transmission of Toxoplasma gondii to humans: a parasite burden study in pig tissues after infection with different strains of Toxoplasma gondii as a function of time and different parasite stages en_US
dc.type Article en_US
dc.citation.issue 7 en_US
dc.citation.jtitle International Journal for Parasitology en_US
dc.citation.volume 48 en_US
dc.citation.pages 555-560 en_US
dc.citation.abbreviation Int J Parasitol en_US


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