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Melarsomine hydrochloride (Cymelarsan((R))) fails to cure horses with Trypanosoma equiperdum OVI parasites in their cerebrospinal fluid

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dc.contributor.author Hebert, L. en_US
dc.contributor.author Guitton, E. en_US
dc.contributor.author Madeline, A. en_US
dc.contributor.author Geraud, T. en_US
dc.contributor.author Zientara, S. en_US
dc.contributor.author Laugier, C. en_US
dc.contributor.author Hans, A. en_US
dc.contributor.author Büscher, P. en_US
dc.contributor.author Cauchard, J. en_US
dc.contributor.author Petry, S. en_US
dc.date.accessioned 2019-06-04T12:21:30Z
dc.date.available 2019-06-04T12:21:30Z
dc.date.issued 2018 en_US
dc.identifier.issn 0304-4017 en_US
dc.identifier.doi http://dx.doi.org/10.1016/j.vetpar.2018.11.005 en_US
dc.identifier.other http://lib.itg.be/pdf/itg/2018/2018vpar0047.pdf en_US
dc.identifier.other 18 en_US
dc.identifier.other ITG-B8A; DBM; U-PARDIA; JIF; DOI; PDF; Abstract; ITMPUB; DSPACE65 en_US
dc.identifier.uri http://hdl.handle.net/10390/10708
dc.description.abstract The aim of this study was to evaluate the ability of melarsomine hydrochloride (Cymelarsan((R))) to cure horses suffering from a nervous form of dourine, a sexually-transmitted disease caused by Trypanosoma equiperdum. The recently described experimental model for assessing drug efficacy against horse trypanosomosis allowed us to obtain eight horses (Welsh pony mares) infected by T. equiperdum with parasites in their cerebrospinal fluid. The Cymelarsan((R)) treatment evaluated consisted of the daily administration of 0.5 mg/kg of Cymelarsan((R)) over 7 days. Two control horses remained untreated, three horses received the treatment 36 days p.i. and three horses received the treatment 16 days p.i. Following treatment, we observed parasite clearance in blood, stabilization of rectal temperature and a relative improvement in the mean packed cell volume levels for all treated horses. However, live parasites were later observed again in the CSF of all treated horses. Our results indicate the inability of Cymelarsan((R)) to reach Trypanozoon located in the central nervous system of infected horses and thus discourage the use of Cymelarsan((R)) to treat animals suffering from a nervous form of dourine. en_US
dc.language English en_US
dc.relation.uri http://www.ncbi.nlm.nih.gov/pubmed/30503091 en_US
dc.title Melarsomine hydrochloride (Cymelarsan((R))) fails to cure horses with Trypanosoma equiperdum OVI parasites in their cerebrospinal fluid en_US
dc.type Article en_US
dc.citation.jtitle Veterinary Parasitology en_US
dc.citation.volume 264 en_US
dc.citation.pages 47-51 en_US
dc.citation.abbreviation Vet Parasitol en_US


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