Selection of potential therapeutic bacteriophages that lyse a CTX-M-15 extended spectrum beta-lactamase producing Salmonella enterica serovar typhi strain from the Democratic Republic of the Congo

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Selection of potential therapeutic bacteriophages that lyse a CTX-M-15 extended spectrum beta-lactamase producing Salmonella enterica serovar typhi strain from the Democratic Republic of the Congo

Kakabadze, E.; Makalatia, K.; Grdzelishvili, N.; Bakuradze, N.; Goderdzishvili, M.; Kusradze, I.; Phoba, M. F.; Lunguya, O.; Lood, C.; Lavigne, R.; Jacobs, J.; Deborggraeve, S.; De Block, T.; Van Puyvelde, S.; Lee, D.; Coffey, A.; Sedrakyan, A.; Soentjens, P.; De Vos, D.; Pirnay, J. P.; Chanishvili, N.

Journal Name:

Viruses

Issue Date:

2018

Volume:

Issue:

DOI:

http://dx.doi.org/10.3390/v10040172

Language:

English

Type:

Article-E

Keywords:

Salmonellosis
Salmonella enterica
Bacterial diseases
Therapeutics
Bacteriophages
Congo-Kinshasa
Africa-Central

Abstract:

Recently, a Salmonella Typhi isolate producing CTX-M-15 extended spectrum beta-lactamase (ESBL) and with decreased ciprofloxacin susceptibility was isolated in the Democratic Republic of the Congo. We have selected bacteriophages that show strong lytic activity against this isolate and have potential for phage-based treatment of S. Typhi, and Salmonella in general.

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