Institute of Tropical Medicine Antwerp
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Cognitive impairment and quality of life of people with epilepsy and neurocysticercosis in Zambia

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Show simple item record Nau, A. L. en_US Mwape, K. E. en_US Wiefek, J. en_US Schmidt, K. en_US Abatih, E. en_US Dorny, P. en_US Praet, N. en_US Chiluba, C. en_US Schmidt, H. en_US Phiri, I. K. en_US Winkler, A. S. en_US Gabriel, S. en_US Blocher, J. en_US 2019-06-04T12:21:57Z 2019-06-04T12:21:57Z 2018 en_US
dc.identifier.issn 1525-5050 en_US
dc.identifier.doi en_US
dc.identifier.other en_US
dc.identifier.other 40 en_US
dc.identifier.other ITG-B6A; ITG-B7B; DBM; U-VHELM; JIF; DOI; PDF; Abstract; ITMPUB; DSPACE65 en_US
dc.description.abstract Cognitive impairment and quality of life (Qol) are important to assess the burden of epilepsy and neurocysticercosis (NCC), which are common but neglected in Sub-Saharan Africa (SSA). The aims of this study were to assess cognitive performance and Qol of people with epilepsy (PWE) in Zambia and to explore differences in PWE with and without NCC. In this community based, cross-sectional case-control-study, 47 PWE and 50 healthy controls completed five neuropsychological tests (Mini Mental State Examination (MMSE), Digit Span, Selective Reminding Test (SRT), Spatial Recall Test (SPART), Test Battery of Attentional Performance (TAP)) and a World Health Organization (WHO) questionnaire of Qol. Comparisons were made between PWE (n=47) and healthy controls (n=50) and between PWE with NCC (n=28) and without NCC (n=19), respectively, using Analysis of Covariance (ANCOVA) and Linear Models (LMs) while correcting for confounders such as age, sex, and schooling years, and adjusting for multiplicity. Working memory, spatial memory, verbal memory, verbal learning, orientation, speech and language reception, visuoconstructive ability, and attentional performance were significantly reduced in PWE compared with healthy controls (ANCOVA and LM, p<0.05). Quality of life of PWE was significantly lower in three domains (psychological, social, environmental) and in overall Qol compared with healthy controls (ANCOVA, p<0.05). There were no significant differences between PWE with NCC and PWE without NCC detected by ANCOVA. Using LM, significant differences between the groups were detected in four tests, indicating worse performance of PWE without NCC in MMSE, Digit Span, SPART, and lower physical Qol. Epilepsy was found to be associated with cognitive impairment and reduced Qol. People with epilepsy due to NCC had similar cognitive impairment and Qol compared with PWE due to other causes. Further studies should investigate the role of different conditions of NCC and the role of seizures on cognition and Qol. en_US
dc.language English en_US
dc.relation.uri en_US
dc.subject Neurocysticercosis en_US
dc.subject Helminthic diseases en_US
dc.subject Zoonoses en_US
dc.subject Neurological disorders en_US
dc.subject Epilepsy en_US
dc.subject Cognitive impairment en_US
dc.subject Zambia en_US
dc.subject Africa-Southern en_US
dc.title Cognitive impairment and quality of life of people with epilepsy and neurocysticercosis in Zambia en_US
dc.type Article en_US
dc.citation.jtitle Epilepsy & Behavior en_US
dc.citation.volume 80 en_US
dc.citation.pages 354-359 en_US
dc.citation.abbreviation Epilepsy Behav en_US

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