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Genetic spatiotemporal anatomy of Plasmodium vivax malaria episodes in Greece, 2009-2013

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dc.contributor.author Spanakos, G. en_US
dc.contributor.author Snounou, G. en_US
dc.contributor.author Pervanidou, D. en_US
dc.contributor.author Alifrangis, M. en_US
dc.contributor.author Rosanas-Urgell, A. en_US
dc.contributor.author Baka, A. en_US
dc.contributor.author Tseroni, M. en_US
dc.contributor.author Vakali, A. en_US
dc.contributor.author Vassalou, E. en_US
dc.contributor.author Patsoula, E. en_US
dc.contributor.author Zeller, H. en_US
dc.contributor.author Van Bortel, W. en_US
dc.contributor.author Hadjichristodoulou, C. en_US
dc.date.accessioned 2019-06-04T12:22:06Z
dc.date.available 2019-06-04T12:22:06Z
dc.date.issued 2018 en_US
dc.identifier.issn 1080-6040 en_US
dc.identifier.doi http://dx.doi.org/10.3201/eid2403.170605 en_US
dc.identifier.other http://lib.itg.be/pdf/itg/2018/2018eidi0541.pdf en_US
dc.identifier.other 20 en_US
dc.identifier.other ITG-B5A; ITG-B12A; DBM; U-MALAR; U-ENTOM; JIF; OAJ; DOI; PDF; PMC; Abstract; ITMPUB; DSPACE65 en_US
dc.identifier.uri http://hdl.handle.net/10390/10766
dc.description.abstract An influx of immigrants is contributing to the reemergence of Plasmodium vivax malaria in Greece; 1 persistent focus of transmission is in Laconia, Peloponnese. We genotyped archived blood samples from a substantial proportion of malaria cases recorded in Greece in 2009-2013 using 8 microsatellite markers and a PvMSP-3alpha gene fragment and plotted their spatiotemporal distribution. High parasite genetic diversity with low multiplicity of infection was observed. A subset of genetically identical/related parasites was restricted to 3 areas in migrants and Greek residents, with some persisting over 2 consecutive transmission periods. We identified 2 hitherto unsuspected additional foci of local transmission: Kardhitsa and Attica. Furthermore, this analysis indicates that several cases in migrants initially classified as imported malaria were actually locally acquired. This study shows the potential for P. vivax to reestablish transmission and counsels public health authorities about the need for vigilance to achieve or maintain sustainable malaria elimination. en_US
dc.language English en_US
dc.relation.uri http://www.ncbi.nlm.nih.gov/pubmed/29460743 en_US
dc.subject Malaria en_US
dc.subject Plasmodium vivax en_US
dc.subject Protozoal diseases en_US
dc.subject Reemerging diseases en_US
dc.subject Greece en_US
dc.subject Europe-South en_US
dc.title Genetic spatiotemporal anatomy of Plasmodium vivax malaria episodes in Greece, 2009-2013 en_US
dc.type Article en_US
dc.citation.issue 3 en_US
dc.citation.jtitle Emerging Infectious Diseases en_US
dc.citation.volume 24 en_US
dc.citation.pages 541-548 en_US
dc.citation.abbreviation Emerg Infect Dis en_US


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