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Genotyping acaricide resistance profiles of Rhipicephalus microplus tick populations from communal land areas of Zimbabwe

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dc.contributor.author Sungirai, M. en_US
dc.contributor.author Baron, S. en_US
dc.contributor.author Moyo, D. Z. en_US
dc.contributor.author De Clercq, P. en_US
dc.contributor.author Maritz-Olivier, C. en_US
dc.contributor.author Madder, M. en_US
dc.date.accessioned 2019-06-04T12:22:06Z
dc.date.available 2019-06-04T12:22:06Z
dc.date.issued 2018 en_US
dc.identifier.issn 1877-959X en_US
dc.identifier.doi http://dx.doi.org/10.1016/j.ttbdis.2017.10.017 en_US
dc.identifier.other http://lib.itg.be/pdf/itg/2018/2018ttbd0002.pdf en_US
dc.identifier.other 48 en_US
dc.identifier.other ITG-B1B; DBM; U-VENTO; JIF; DOI; PDF; Abstract; ITMPUB; DSPACE65 en_US
dc.identifier.uri http://hdl.handle.net/10390/10767
dc.description.abstract Acaricide resistance is one of the greatest threats towards the successful control of vector ticks worldwide. Communal farmers of Zimbabwe use amitraz as the most common acaricide with occasional usage of pyrethroids and organophosphates. As a strategy towards developing an effective acaricide resistance management system in Zimbabwe, screening was done by genotyping Rhipicephalus microplus tick populations using molecular markers associated with resistance to these chemicals. The frequency of the mutant allele for the octopamine/tyramine receptor marker associated with amitraz resistance was high (0.55) and a large proportion 78.5% (288/367) of heterozygote genotypes were observed indicating balancing selection. Of the communal dipping tanks where R. microplus occurred 37.8% (39/103) showed complete resistance genotypes for amitraz. The carboxylesterase marker that has been associated with resistance to organophosphate and pyrethroids indicated no selection pressure in these chemical groups with a low frequency (0.052) of the mutant allele and 89.6% (329/367) sampled ticks showing homozygous susceptibility genotypes. Heterozygous genotypes were present at 27.2% (28/103) of the dipping tanks. The L641 mutation in the voltage-gated sodium channel gene associated with pyrethroid resistance was not detected in Zimbabwean samples. This would suggest a different mechanism of resistance to pyrethroids in these tick populations. Sequence analysis of the octopamine/tyramine receptor gene revealed the presence of other mutations in this region, it will be important to investigate their association with amitraz resistance. These results present the first molecular genotyping of resistance profiles of R. microplus tick populations from Zimbabwe. en_US
dc.language English en_US
dc.relation.uri http://www.ncbi.nlm.nih.gov/pubmed/29103950 en_US
dc.subject Ticks en_US
dc.subject Rhipicephalus microplus en_US
dc.subject Entomology en_US
dc.subject Control en_US
dc.subject Acaricides en_US
dc.subject Zimbabwe en_US
dc.subject Africa-Southern en_US
dc.title Genotyping acaricide resistance profiles of Rhipicephalus microplus tick populations from communal land areas of Zimbabwe en_US
dc.type Article en_US
dc.citation.issue 1 en_US
dc.citation.jtitle Ticks and Tick-Borne Diseases en_US
dc.citation.volume 9 en_US
dc.citation.pages 2-9 en_US
dc.citation.abbreviation Ticks Tick Borne Dis en_US


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