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Intestinal parasites: associations with intestinal and systemic inflammation

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dc.contributor.author Zavala, G. A. en_US
dc.contributor.author Garcia, O. P. en_US
dc.contributor.author Camacho, M. en_US
dc.contributor.author Ronquillo, D. en_US
dc.contributor.author Campos-Ponce, M. en_US
dc.contributor.author Doak, C. en_US
dc.contributor.author Polman, K. en_US
dc.contributor.author Rosado, J. L. en_US
dc.date.accessioned 2019-06-04T12:22:18Z
dc.date.available 2019-06-04T12:22:18Z
dc.date.issued 2018 en_US
dc.identifier.issn 0141-9838 en_US
dc.identifier.doi http://dx.doi.org/10.1111/pim.12518 en_US
dc.identifier.other http://lib.itg.be/pdf/itg/2018/2018pimme12518.pdf en_US
dc.identifier.other 6 pp. en_US
dc.identifier.other 50 en_US
dc.identifier.other ITG-B7A; DBM; U-MHELM; JIF; DOI; PDF; OAA; E-only; Abstract; ITMPUB; DSPACE65 en_US
dc.identifier.uri http://hdl.handle.net/10390/10784
dc.description.abstract AIMS: Evaluate associations between intestinal parasitic infection with intestinal and systemic inflammatory markers in school-aged children with high rates of obesity. METHODS AND RESULTS: Plasma concentrations of CRP, leptin, TNF-alpha, IL-6 and IL-10 were measured as systemic inflammation markers and count of stool leukocytes as marker of intestinal inflammation in 291 children (6-10y). Intestinal parasitic infection was measured by stool examination. Logistic regression analyses were performed to determine the odds of having high inflammatory markers for each parasite or group of parasites as compared to parasite-free children while adjusting for sex, age, mother educational level and % of body fat. The prevalence of soil transmitted helminths and intestinal protozoa infections was 12% and 36%, respectively. Parasitic infection was not associated with CRP, IL-6, IL-10 or TNF-alpha. Children infected with Ascaris lumbricoides (aOR: 5.91, 95%CI: 1.97-17.70) and Entamoeba coli (aOR: 8.46, 95%CI: 2.85-25.14) were more likely to have higher stool leucocytes than parasite-free children. Children with multiple-infections (aOR: 10.60, 95%CI: 2.85-25.14) were more likely to have higher leptin concentrations than parasite-free children. CONCLUSION: Intestinal parasitic infection was not associated with systemic inflammation, but was associated with intestinal inflammation. Having multiple-infections were associated with higher leptin concentrations. This article is protected by copyright. All rights reserved. en_US
dc.language English en_US
dc.relation.uri http://www.ncbi.nlm.nih.gov/pubmed/29364525 en_US
dc.subject Parasitic diseases en_US
dc.subject Intestinal parasites en_US
dc.subject Inflammation en_US
dc.title Intestinal parasites: associations with intestinal and systemic inflammation en_US
dc.type Article-E en_US
dc.citation.issue 4 en_US
dc.citation.jtitle Parasite Immunology en_US
dc.citation.volume 40 en_US
dc.citation.pages e12518 en_US
dc.citation.abbreviation Parasite Immunol en_US


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