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Genetic diversity of Mycobacterium tuberculosis from Para, Brazil, reveals a higher frequency of ancestral strains than previously reported in South America

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dc.contributor.author Conceicao, E. C. en_US
dc.contributor.author Rastogi, N. en_US
dc.contributor.author Couvin, D. en_US
dc.contributor.author Lopes, M. L. en_US
dc.contributor.author Furlaneto, I. P. en_US
dc.contributor.author Gomes, H. M. en_US
dc.contributor.author Vasconcellos, S. E. G. en_US
dc.contributor.author Suffys, P. N. en_US
dc.contributor.author Schneider, M. P. C. en_US
dc.contributor.author de Sousa, M. S. en_US
dc.contributor.author Sola, C. en_US
dc.contributor.author de Paula Souza E Guimaraes, R. J. en_US
dc.contributor.author Duarte, R. S. en_US
dc.contributor.author Batista Lima, K. V. en_US
dc.date.accessioned 2019-06-04T12:22:21Z
dc.date.available 2019-06-04T12:22:21Z
dc.date.issued 2017 en_US
dc.identifier.issn 1567-1348 en_US
dc.identifier.doi http://dx.doi.org/10.1016/j.meegid.2017.10.021 en_US
dc.identifier.other http://lib.itg.be/pdf/itg/2017/2017igev0062.pdf en_US
dc.identifier.other 40 en_US
dc.identifier.other ITG-B8B; DBM; U-MYCOB; JIF; DOI; PDF; Abstract; ITMPUB; DSPACE65 en_US
dc.identifier.uri http://hdl.handle.net/10390/10790
dc.description.abstract There is only scarce information available on genotypic diversity of the Mycobacterium tuberculosis complex (MTBC) clinical isolates circulating in the Northern part of Brazil, a relatively neglected region regarding research on tuberculosis. We therefore characterized 980 MTBC clinical isolates from the state of Para, by spoligotyping and data was compared with patterns from around the world, besides analyzing drug susceptibility, and collecting sociodemographic data. We also performed 24 loci MIRU-VNTR typing to evaluate phylogenetic inferences among the East-African-Indian (EAI) lineage strains. The Geographic Information System analyses were performed to generate a descriptive visualization of MTBC strain distribution in the region. A total of 249 different spoligopatterns primarily belonging to evolutionary recent Euro-American lineages, as well as Central-Asian, Manu and ancestral EAI lineages, were identified, in addition to strains with reportedly unknown lineage signatures. The most frequent lineages were Latin American Mediterranean, T and Haarlem. Interestingly, EAI lineage strains were found in a significantly higher proportion in comparison with previous studies from South America. Regarding EAI lineage, the absence of spacers 4-9 and 23-24 co-related to 24 loci MIRU-VNTRs may suggest a close evolutionary relationship between such strains in Para and those prevalent in Mozambique, which might have contributed to the genetic diversity of MTBC strains in this region. en_US
dc.language English en_US
dc.relation.uri http://www.ncbi.nlm.nih.gov/pubmed/29081357 en_US
dc.subject Tuberculosis en_US
dc.subject Bacterial diseases en_US
dc.subject Mycobacterium tuberculosis en_US
dc.subject Genetic diversity en_US
dc.subject Brazil en_US
dc.subject America-Latin en_US
dc.title Genetic diversity of Mycobacterium tuberculosis from Para, Brazil, reveals a higher frequency of ancestral strains than previously reported in South America en_US
dc.type Article en_US
dc.citation.jtitle Infection, Genetics and Evolution en_US
dc.citation.volume 56 en_US
dc.citation.pages 62-72 en_US
dc.citation.abbreviation Infect Genet Evol en_US


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