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The study of trypanosome species circulating in domestic animals in two human African trypanosomiasis foci of Cote d'Ivoire identifies pigs and cattle as potential reservoirs of Trypanosoma brucei gambiense

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dc.contributor.author N'Djetchi, M. K. en_US
dc.contributor.author Ilboudo, H. en_US
dc.contributor.author Koffi, M. en_US
dc.contributor.author Kabore, J. en_US
dc.contributor.author Kabore, J. W. en_US
dc.contributor.author Kaba, D. en_US
dc.contributor.author Courtin, F. en_US
dc.contributor.author Coulibaly, B. en_US
dc.contributor.author Fauret, P. en_US
dc.contributor.author Kouakou, L. en_US
dc.contributor.author Ravel, S. en_US
dc.contributor.author Deborggraeve, S. en_US
dc.contributor.author Solano, P. en_US
dc.contributor.author De Meeus, T. en_US
dc.contributor.author Bucheton, B. en_US
dc.contributor.author Jamonneau, V. en_US
dc.date.accessioned 2019-06-04T12:22:36Z
dc.date.available 2019-06-04T12:22:36Z
dc.date.issued 2017 en_US
dc.identifier.issn 1935-2727 en_US
dc.identifier.doi http://dx.doi.org/10.1371/journal.pntd.0005993 en_US
dc.identifier.other http://lib.itg.be/pdf/itg/2017/2017pntd5993.pdf en_US
dc.identifier.other 16 pp. en_US
dc.identifier.other 69 en_US
dc.identifier.other ITG-B12A; DBM; U-DIABAC; JIF; DOI; PDF; PMC; OAJ; E-only; Abstract; ITMPUB; DSPACE65 en_US
dc.identifier.uri http://hdl.handle.net/10390/10810
dc.description.abstract BACKGROUND: Important control efforts have led to a significant reduction of the prevalence of human African trypanosomiasis (HAT) in Cote d'Ivoire, but the disease is still present in several foci. The existence of an animal reservoir of Trypanosoma brucei gambiense may explain disease persistence in these foci where animal breeding is an important source of income but where the prevalence of animal African trypanosomiasis (AAT) is unknown. The aim of this study was to identify the trypanosome species circulating in domestic animals in both Bonon and Sinfra HAT endemic foci. METHODOLOGY/PRINCIPAL FINDINGS: 552 domestic animals (goats, pigs, cattle and sheep) were included. Blood samples were tested for trypanosomes by microscopic observation, species-specific PCR for T. brucei sl, T. congolense, T. vivax and subspecies-specific PCR for T. b. gambiense and T. b. gambiense immune trypanolysis (TL). Infection rates varied significantly between animal species and were by far the highest in pigs (30%). T. brucei s.l was the most prevalent trypanosome species (13.7%) followed by T. congolense. No T. b. gambiense was identified by PCR while high TL positivity rates were observed using T. b. gambiense specific variants (up to 27.6% for pigs in the Bonon focus). CONCLUSION: This study shows that domestic animals are highly infected by trypanosomes in the studied foci. This was particularly true for pigs, possibly due to a higher exposure of these animals to tsetse flies. Whereas T. brucei s.l. was the most prevalent species, discordant results were obtained between PCR and TL regarding T. b. gambiense identification. It is therefore crucial to develop better tools to study the epidemiological role of potential animal reservoir for T. b. gambiense. Our study illustrates the importance of "one health" approaches to reach HAT elimination and contribute to AAT control in the studied foci. en_US
dc.language English en_US
dc.relation.uri http://www.ncbi.nlm.nih.gov/pubmed/29045405 en_US
dc.subject Trypanosomiasis-African en_US
dc.subject HAT en_US
dc.subject Sleeping sickness en_US
dc.subject Protozoal diseases en_US
dc.subject Trypanosoma brucei gambiense en_US
dc.subject Reservoirs en_US
dc.subject Animals en_US
dc.subject Cattle en_US
dc.subject Pigs en_US
dc.subject C�te d'Ivoire en_US
dc.subject Africa-West en_US
dc.title The study of trypanosome species circulating in domestic animals in two human African trypanosomiasis foci of Cote d'Ivoire identifies pigs and cattle as potential reservoirs of Trypanosoma brucei gambiense en_US
dc.type Article-E en_US
dc.citation.issue 10 en_US
dc.citation.jtitle PLoS Neglected Tropical Diseases en_US
dc.citation.volume 11 en_US
dc.citation.pages e0005993 en_US
dc.citation.abbreviation PLoS Negl Trop Dis en_US


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