Institute of Tropical Medicine Antwerp
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The biology and epidemiology of Mycobacterium africanum

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Show simple item record Yeboah-Manu, D. en_US de Jong, B. C. en_US Gehre, F. en_US 2019-06-04T12:22:44Z 2019-06-04T12:22:44Z 2017 en_US
dc.identifier.issn 0065-2598 en_US
dc.identifier.doi en_US
dc.identifier.other This item is not available in the ITG Library en_US
dc.identifier.other ITG-B2A; ITG-BLB; DBM; U-MYCOB; JIF; DOI; Abstract; Not available; ITMPUB; DSPACE65 en_US
dc.description.abstract West Africa is the only region in the world where six out of seven mycobacterial lineages of human importance are endemic. In particular, two evolutionary ancient lineages, Mycobacterium africanum West Africa 1 (MTBC Lineage 5) and M. africanum West Africa 2 (MTBC Lineage 6) are of interest as they cause up to 40% of all pulmonary TB cases in some West African countries. Although these M. africanum lineages are closely related to M. tuberculosis sensu stricto lineages, they differ significantly in respect to biology, epidemiology and in their potential to cause disease in humans. Most importantly the M. africanum lineages are exclusive to West Africa. Although the exact mechanisms underlying this geographical restriction are still not understood, it is increasingly suspected that this is due to an adaptation of the bacteria to West African host populations. In this chapter, we summarize the geographical distribution of the M. africanum lineages within the region, describe biological and clinical differences and the consequent implications for TB control in West Africa. We also try to shed light on the geographical restriction, based on recently published analyses on whole genomes of M. africanum isolates. en_US
dc.language English en_US
dc.relation.uri en_US
dc.subject Mycobacterium africanum en_US
dc.subject Bacteriology en_US
dc.subject Epidemiology en_US
dc.subject Distribution en_US
dc.subject Africa-West en_US
dc.title The biology and epidemiology of Mycobacterium africanum en_US
dc.type Article en_US
dc.citation.jtitle Advances in Experimental Medicine and Biology en_US
dc.citation.volume 1019 en_US
dc.citation.pages 117-133 en_US
dc.citation.abbreviation Adv Exp Med Biol en_US

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