Institute of Tropical Medicine Antwerp
Foundation of Public Utility

World Health Organization estimates of the global and regional disease burden of 22 foodborne bacterial, protozoal, and viral diseases, 2010: a data synthesis

DSpace/Manakin Repository

Show simple item record Kirk, M. D. en_US Pires, S. M. en_US Black, R. E. en_US Caipo, M. en_US Crump, J. A. en_US Devleesschauwer, B. en_US Dopfer, D. en_US Fazil, A. en_US Fischer-Walker, C. L. en_US Hald, T. en_US Hall, A. J. en_US Keddy, K. H. en_US Lake, R. J. en_US Lanata, C. F. en_US Torgerson, P. R. en_US Havelaar, A. H. en_US Angulo, F. J. en_US 2019-06-04T12:22:46Z 2019-06-04T12:22:46Z 2015 en_US
dc.identifier.issn 1549-1277 en_US
dc.identifier.doi en_US
dc.identifier.other en_US
dc.identifier.other 21 pp. en_US
dc.identifier.other ITG-B6B; DBM; U-VHELM; JIF; DOI; PDF; OAJ; E-only; Abstract; ITMPUB; DSPACE65 en_US
dc.description.abstract BACKGROUND: Foodborne diseases are important worldwide, resulting in considerable morbidity and mortality. To our knowledge, we present the first global and regional estimates of the disease burden of the most important foodborne bacterial, protozoal, and viral diseases. METHODS AND FINDINGS: We synthesized data on the number of foodborne illnesses, sequelae, deaths, and Disability Adjusted Life Years (DALYs), for all diseases with sufficient data to support global and regional estimates, by age and region. The data sources included varied by pathogen and included systematic reviews, cohort studies, surveillance studies and other burden of disease assessments. We sought relevant data circa 2010, and included sources from 1990-2012. The number of studies per pathogen ranged from as few as 5 studies for bacterial intoxications through to 494 studies for diarrheal pathogens. To estimate mortality for Mycobacterium bovis infections and morbidity and mortality for invasive non-typhoidal Salmonella enterica infections, we excluded cases attributed to HIV infection. We excluded stillbirths in our estimates. We estimate that the 22 diseases included in our study resulted in two billion (95% uncertainty interval [UI] 1.5-2.9 billion) cases, over one million (95% UI 0.89-1.4 million) deaths, and 78.7 million (95% UI 65.0-97.7 million) DALYs in 2010. To estimate the burden due to contaminated food, we then applied proportions of infections that were estimated to be foodborne from a global expert elicitation. Waterborne transmission of disease was not included. We estimate that 29% (95% UI 23-36%) of cases caused by diseases in our study, or 582 million (95% UI 401-922 million), were transmitted by contaminated food, resulting in 25.2 million (95% UI 17.5-37.0 million) DALYs. Norovirus was the leading cause of foodborne illness causing 125 million (95% UI 70-251 million) cases, while Campylobacter spp. caused 96 million (95% UI 52-177 million) foodborne illnesses. Of all foodborne diseases, diarrheal and invasive infections due to non-typhoidal S. enterica infections resulted in the highest burden, causing 4.07 million (95% UI 2.49-6.27 million) DALYs. Regionally, DALYs per 100,000 population were highest in the African region followed by the South East Asian region. Considerable burden of foodborne disease is borne by children less than five years of age. Major limitations of our study include data gaps, particularly in middle- and high-mortality countries, and uncertainty around the proportion of diseases that were foodborne. CONCLUSIONS: Foodborne diseases result in a large disease burden, particularly in children. Although it is known that diarrheal diseases are a major burden in children, we have demonstrated for the first time the importance of contaminated food as a cause. There is a need to focus food safety interventions on preventing foodborne diseases, particularly in low- and middle-income settings. en_US
dc.language English en_US
dc.relation.uri en_US
dc.subject Foodborne diseases en_US
dc.subject Protozoal diseases en_US
dc.subject Bacterial diseases en_US
dc.subject Viral diseases en_US
dc.subject Disease burden en_US
dc.subject Epidemiology en_US
dc.subject Prevalence en_US
dc.subject Incidence en_US
dc.subject Mortality en_US
dc.subject Estimation en_US
dc.subject World Health Organization (WHO) en_US
dc.subject WHO en_US
dc.subject DALYs en_US
dc.subject Case fatality rates en_US
dc.subject Methodology en_US
dc.subject Global en_US
dc.title World Health Organization estimates of the global and regional disease burden of 22 foodborne bacterial, protozoal, and viral diseases, 2010: a data synthesis en_US
dc.type Article-E en_US
dc.citation.issue 12 en_US
dc.citation.jtitle PLoS Medicine en_US
dc.citation.volume 12 en_US
dc.citation.pages e1001921 en_US
dc.citation.abbreviation PLoS Med en_US

Files in this item

This item appears in the following Collection(s)

Show simple item record