False rifampicin resistance in Xpert Ultra applied to lymph node aspirate: a case report

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False rifampicin resistance in Xpert Ultra applied to lymph node aspirate: a case report

Ng, K. C. S.; Rigouts, L.; de Jong, B. C.; Lynen, L.

Journal Name:

Open Forum Infectious Diseases

Issue Date:

2020

Volume:

Issue:

Pages:

ofaa204

DOI:

http://dx.doi.org/10.1093/ofid/ofaa204

Language:

English

Type:

Article-E

Keywords:

Tuberculosis-rifampicin-resistant
Bacterial diseases
Xpert Ultra
Case studies
Belgium
Europe-West

Abstract:

A 36-year-old male patient was diagnosed with tuberculosis in Antwerp, Belgium, in May 2018. His lymph node aspirate initially tested rifampicin resistant in Xpert MTB/RIF Ultra, but tested susceptible in all other tests including targeted deep sequencing due to a rare matrix effect in the Xpert MTB/RIF Ultra reaction tube.

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