Institute of Tropical Medicine Antwerp
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Immune trypanolysis test as a promising bioassay to monitor the elimination of gambiense human African trypanosomiasis

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Show simple item record Dama, E. en_US Camara, O. en_US Kaba, D. en_US Koffi, M. en_US Camara, M. en_US Compaore, C. en_US Ilboudo, H. en_US Courtin, F. en_US Kabore, J. en_US N'Gouan, E. K. en_US Büscher, P. en_US Lejon, V. en_US Bucheton, B. en_US Jamonneau, V. en_US 2020-08-25T09:38:23Z 2020-08-25T09:38:23Z 2019 en_US
dc.identifier.issn 1252-607X en_US
dc.identifier.doi en_US
dc.identifier.other ITG-B11A; DBM; U-PARDIA; JIF; DOI; PDF; Abstract; ITMPUB; DSPACE68 en_US
dc.description.abstract The World Health Organization (WHO) has set the goal of gambiense-Human African trypanosomiasis (HAT) elimination as a public health problem for 2020 and interruption of transmission in humans for 2030. In this context, it is crucial to monitor progress towards these targets using accurate tools to assess the level of transmission in a given area. The aim of this study was to investigate the relevance of the immune trypanolysis test (TL) as a population-based bioassay to evaluate Trypanosoma brucei gambiense transmission in various epidemiological contexts. Significant correlations were observed between HAT endemicity levels and the percentage of TL-positive individuals in the population. TL therefore appears to be a suitable population-based biomarker of the intensity of transmission. In addition to being used as a tool to assess the HAT status at an individual level, assessing the proportion of TL positive individuals in the population appears as a promising and easy alternative to monitor the elimination of gambiense HAT in a given area. en_US
dc.language English en_US
dc.relation.uri en_US
dc.subject Trypanosomiasis-African en_US
dc.subject Sleeping sickness en_US
dc.subject HAT en_US
dc.subject Trypanosoma brucei gambiense en_US
dc.subject Protozoal diseases en_US
dc.subject Elimination en_US
dc.subject Diagnostic tests en_US
dc.subject Africa-West en_US
dc.title Immune trypanolysis test as a promising bioassay to monitor the elimination of gambiense human African trypanosomiasis en_US
dc.type Article en_US
dc.citation.jtitle Parasite en_US
dc.citation.volume 26 en_US
dc.citation.pages 68 en_US
dc.citation.abbreviation Parasite en_US

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