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Immune trypanolysis test as a promising bioassay to monitor the elimination of gambiense human African trypanosomiasis

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dc.contributor.author Dama, E. en_US
dc.contributor.author Camara, O. en_US
dc.contributor.author Kaba, D. en_US
dc.contributor.author Koffi, M. en_US
dc.contributor.author Camara, M. en_US
dc.contributor.author Compaore, C. en_US
dc.contributor.author Ilboudo, H. en_US
dc.contributor.author Courtin, F. en_US
dc.contributor.author Kabore, J. en_US
dc.contributor.author N'Gouan, E. K. en_US
dc.contributor.author Büscher, P. en_US
dc.contributor.author Lejon, V. en_US
dc.contributor.author Bucheton, B. en_US
dc.contributor.author Jamonneau, V. en_US
dc.date.accessioned 2020-08-25T09:38:23Z
dc.date.available 2020-08-25T09:38:23Z
dc.date.issued 2019 en_US
dc.identifier.issn 1252-607X en_US
dc.identifier.doi http://dx.doi.org/10.1051/parasite/2019066 en_US
dc.identifier.other ITG-B11A; DBM; U-PARDIA; JIF; DOI; PDF; Abstract; ITMPUB; DSPACE68 en_US
dc.identifier.uri http://hdl.handle.net/10390/10911
dc.description.abstract The World Health Organization (WHO) has set the goal of gambiense-Human African trypanosomiasis (HAT) elimination as a public health problem for 2020 and interruption of transmission in humans for 2030. In this context, it is crucial to monitor progress towards these targets using accurate tools to assess the level of transmission in a given area. The aim of this study was to investigate the relevance of the immune trypanolysis test (TL) as a population-based bioassay to evaluate Trypanosoma brucei gambiense transmission in various epidemiological contexts. Significant correlations were observed between HAT endemicity levels and the percentage of TL-positive individuals in the population. TL therefore appears to be a suitable population-based biomarker of the intensity of transmission. In addition to being used as a tool to assess the HAT status at an individual level, assessing the proportion of TL positive individuals in the population appears as a promising and easy alternative to monitor the elimination of gambiense HAT in a given area. en_US
dc.language English en_US
dc.relation.uri http://www.ncbi.nlm.nih.gov/pubmed/31755862 en_US
dc.subject Trypanosomiasis-African en_US
dc.subject Sleeping sickness en_US
dc.subject HAT en_US
dc.subject Trypanosoma brucei gambiense en_US
dc.subject Protozoal diseases en_US
dc.subject Elimination en_US
dc.subject Diagnostic tests en_US
dc.subject Africa-West en_US
dc.title Immune trypanolysis test as a promising bioassay to monitor the elimination of gambiense human African trypanosomiasis en_US
dc.type Article en_US
dc.citation.jtitle Parasite en_US
dc.citation.volume 26 en_US
dc.citation.pages 68 en_US
dc.citation.abbreviation Parasite en_US


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