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Mucosal lactoferrin response to genital tract infections is associated with iron and nutritional biomarkers in young Burkinabe women

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Show simple item record Roberts, S. A. en_US Brabin, L. en_US Diallo, S. en_US Gies, S. en_US Nelson, A. en_US Stewart, C. en_US Swinkels, D. W. en_US Geurts-Moespot, A. J. en_US Kazienga, A. en_US Ouedraogo, S. en_US D'Alessandro, U. en_US Tinto, H. en_US Brabin, B. J. en_US 2020-08-25T09:38:43Z 2020-08-25T09:38:43Z 2019 en_US
dc.identifier.issn 0954-3007 en_US
dc.identifier.doi en_US
dc.identifier.other en_US
dc.identifier.other 37 en_US
dc.identifier.other ITG-B4X; DBM; U-MALAR; JIF; DOI; PDF; Abstract; ITMPUB; DSPACE68 en_US
dc.description.abstract BACKGROUND/OBJECTIVES: The iron-binding affinity of vaginal lactoferrin (Lf) reduces iron available to genital pathogens. We describe host reproductive, nutritional, infection and iron biomarker profiles affecting vaginal Lf concentration in young nulliparous and primigravid women in Burkina Faso. SUBJECTS/METHODS: Vaginal eluates from women who had participated in a randomized, controlled periconceptional iron supplementation trial were used to measure Lf using a competitive double-sandwich ELISA. For this analysis samples from both trial arms were combined and pregnant and non-pregnant cohorts compared. Following randomization Lf was measured after 18 months (end assessment) for women remaining non-pregnant, and at two antenatal visits for those becoming pregnant. Associations between log Lf levels and demographic, anthropometric, infection and iron biomarker variables were assessed using linear mixed models. RESULTS: Lf samples were available for 712 non-pregnant women at end assessment and for 303 women seen at an antenatal visit. Lf concentrations of pregnant women were comparable to those of non-pregnant, sexually active women. Lf concentration increased with mid-upper-arm circumference, (P = 0.047), body mass index (P = 0.018), Trichomonas vaginalis (P < 0.001) infection, bacterial vaginosis (P < 0.001), serum C-reactive protein (P = 0.048) and microbiota community state types III/IV. Adjusted Lf concentration was positively associated with serum hepcidin (P = 0.047), serum ferritin (P = 0.018) and total body iron stores (P = 0.042). There was evidence that some women maintained persistently high or low Lf concentrations from before, and through, pregnancy. CONCLUSION: Lf concentrations increased with genital infection, higher BMI, MUAC, body iron stores and hepcidin, suggesting nutritional and iron status influence homeostatic mechanisms controlling vaginal Lf responses. en_US
dc.language English en_US
dc.relation.uri en_US
dc.subject Genital tract infections en_US
dc.subject Sexually transmitted diseases en_US
dc.subject STD en_US
dc.subject Women en_US
dc.subject Burkina Faso en_US
dc.subject Africa-West en_US
dc.title Mucosal lactoferrin response to genital tract infections is associated with iron and nutritional biomarkers in young Burkinabe women en_US
dc.type Article en_US
dc.citation.issue 11 en_US
dc.citation.jtitle European Journal of Clinical Nutrition en_US
dc.citation.volume 73 en_US
dc.citation.pages 1464-1472 en_US
dc.citation.abbreviation Eur J Clin Nutr en_US

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