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Aetiology of acute febrile illness in children in a high malaria transmission area in West Africa

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Show simple item record Kabore, B. en_US Post, A. en_US Lompo, P. en_US Bognini, J. D. en_US Diallo, S. en_US Kam, B. T. D. en_US Rahamat-Langendoen, J. en_US Wertheim, H. F. L. en_US van Opzeeland, F. en_US Langereis, J. D. en_US de Jonge, M. I. en_US Tinto, H. en_US Jacobs, J. en_US van der Ven, A. J. en_US de Mast, Q. en_US 2020-08-25T09:54:24Z 2020-08-25T09:54:24Z 2020 en_US
dc.identifier.issn 1198-743X en_US
dc.identifier.doi en_US
dc.identifier.other ITG-C13A; DCS; U-TLM; JIF; DOI; CPDF; Abstract; ITMPUB; DSPACE68 en_US
dc.description.abstract OBJECTIVES: Areas with declining malaria transmission in sub-Saharan Africa have recently witnessed important changes in the aetiology of childhood acute febrile illness (AFI). Here, we describe the aetiology of AFI in a high malaria transmission area in rural Burkina Faso. METHODS: In a prospective hospital-based diagnostic study, children aged 3 months to 15 years with AFI were recruited and assessed using a systematic diagnostic protocol, including blood cultures, whole blood PCR on a selection of bacterial pathogens, malaria diagnostics and a multiplex PCR on nasopharyngeal swabs targeting 21 viral and 4 bacterial respiratory pathogens. RESULTS: 589 children with AFI were enrolled from whom an infectious disease was considered in 575 cases. Acute respiratory tract infections, malaria and invasive bacterial infections (IBI) accounted for 179 (31.1%), 175 (30.4%) and 75 (13%) of AFI cases, respectively; 16 (21.3%) of IBI cases also had malarial parasitaemia. A viral pathogen was demonstrated from the nasopharynx in 157 (90.7%) of children with respiratory tract symptoms. Out of all children with viral respiratory tract infections, 154 (92.4% received antibiotics whereas no antibiotic was given in 13 (17%) of IBI cases. CONCLUSIONS: Viral respiratory infections are a common cause of childhood AFI in high malaria transmission areas, next to malaria and IBI. These findings highlight the importance of interventions to improve targeted treatment with antimicrobials. Most patients with viral infections received antibiotics unnecessarily while a considerable number with IBI did not receive antibiotics. CLINICAL TRIAL REGISTRATION: NCT02669823. en_US
dc.language English en_US
dc.relation.uri en_US
dc.subject Acute febrile illness en_US
dc.subject Fever en_US
dc.subject Malaria en_US
dc.subject Protozoal diseases en_US
dc.subject Children en_US
dc.subject Africa-West en_US
dc.title Aetiology of acute febrile illness in children in a high malaria transmission area in West Africa en_US
dc.type Article-P en_US
dc.citation.jtitle Clinical Microbiology and Infection en_US
dc.citation.abbreviation Clin Microbiol Infect en_US

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