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Gambiense human African trypanosomiasis sequelae after treatment: a follow-up study 12 years after treatment

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dc.contributor.author Mudji, J. en_US
dc.contributor.author Blum, A. en_US
dc.contributor.author Grize, L. en_US
dc.contributor.author Wampfler, R. en_US
dc.contributor.author Ruf, M.T. en_US
dc.contributor.author Cnops, L. en_US
dc.contributor.author Nickel, B. en_US
dc.contributor.author Burri, C. en_US
dc.contributor.author Blum, J. en_US
dc.date.accessioned 2020-08-25T09:54:35Z
dc.date.available 2020-08-25T09:54:35Z
dc.date.issued 2020 en_US
dc.identifier.issn 2414-6366 en_US
dc.identifier.doi http://dx.doi.org/10.3390/tropicalmed5010010 en_US
dc.identifier.other ITG-C6A; DCS; U-HIVNTD; JIF; DOI; CPDF; Abstract; ITMPUB; DSPACE68 en_US
dc.identifier.uri http://hdl.handle.net/10390/11044
dc.description.abstract The clinical presentation of Human African Trypanosomiasis (HAT) due to Trypanosoma brucei gambiense is well known, but knowledge on long-term sequelae is limited. In the frame of studies conducted between 2004 and 2005 in the Democratic Republic of the Congo (DRC), the prevalence of HAT related signs and symptoms were evaluated before the start of treatment and at the end of treatment. To explore possible long-term sequelae, the same clinical parameters were assessed in 2017 in 51 first stage and 18 second stage HAT patients. Signs and symptoms 12-13 years after treatment were compared to before and immediately after treatment and to controls matched for sex and age (+/-5 years). In first stage HAT patients, the prevalence of all signs and symptoms decreased compared to before treatment but were still higher after 12-13 years than immediately at the end of treatment and in the control group. In second stage HAT patients, all HAT-specific findings had continuously decreased to the point where they were in the range of the healthy control group. In a selection of oligosymptomatic first stage HAT patients, no trypanosomes were detected in the blood by microscopic examination or PCR. An oligosymptomatic presentation of HAT due to the persistence of parasites in compartments, where first stage HAT medications do not penetrate, could not be ruled out. en_US
dc.language English en_US
dc.relation.uri http://www.ncbi.nlm.nih.gov/pubmed/31940846 en_US
dc.subject Trypanosomiasis-African en_US
dc.subject Sleeping sickness en_US
dc.subject HAT en_US
dc.subject Protozoal diseases en_US
dc.subject Trypanosoma brucei gambiense en_US
dc.subject Treatment en_US
dc.title Gambiense human African trypanosomiasis sequelae after treatment: a follow-up study 12 years after treatment en_US
dc.type Article-E en_US
dc.citation.issue 1 en_US
dc.citation.jtitle Tropical Medicine and International Health en_US
dc.citation.volume 5 en_US
dc.citation.abbreviation Trop Med Infect Dis en_US


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