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The Severe Typhoid Fever in Africa program: study design and methodology to assess disease severity, host immunity, and carriage associated with invasive salmonellosis

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dc.contributor.author Park, S. E. en_US
dc.contributor.author Toy, T. en_US
dc.contributor.author Cruz Espinoza, L. M. en_US
dc.contributor.author Panzner, U. en_US
dc.contributor.author Mogeni, O. D. en_US
dc.contributor.author Im, J. en_US
dc.contributor.author Poudyal, N. en_US
dc.contributor.author Pak, G. D. en_US
dc.contributor.author Seo, H. en_US
dc.contributor.author Chon, Y. en_US
dc.contributor.author Schutt-Gerowitt, H. en_US
dc.contributor.author Mogasale, V. en_US
dc.contributor.author Ramani, E. en_US
dc.contributor.author Dey, A. en_US
dc.contributor.author Park, J. Y. en_US
dc.contributor.author Kim, J. H. en_US
dc.contributor.author Seo, H. J. en_US
dc.contributor.author Jeon, H. J. en_US
dc.contributor.author Haselbeck, A. en_US
dc.contributor.author Conway, R. K. en_US
dc.contributor.author Macwright, W. en_US
dc.contributor.author Adu-Sarkodie, Y. en_US
dc.contributor.author Owusu-Dabo, E. en_US
dc.contributor.author Osei, I. en_US
dc.contributor.author Owusu, M. en_US
dc.contributor.author Rakotozandrindrainy, R. en_US
dc.contributor.author Soura, A. B. en_US
dc.contributor.author Kabore, L. P. en_US
dc.contributor.author Teferi, M. en_US
dc.contributor.author Okeke, I. N. en_US
dc.contributor.author Kehinde, A. en_US
dc.contributor.author Popoola, O. en_US
dc.contributor.author Jacobs, J. en_US
dc.contributor.author Lunguya Metila, O. en_US
dc.contributor.author Meyer, C. G. en_US
dc.contributor.author Crump, J. A. en_US
dc.contributor.author Elias, S. en_US
dc.contributor.author MacLennan, C. A. en_US
dc.contributor.author Parry, C. M. en_US
dc.contributor.author Baker, S. en_US
dc.contributor.author Mintz, E. D. en_US
dc.contributor.author Breiman, R. F. en_US
dc.contributor.author Clemens, J. D. en_US
dc.contributor.author Marks, F. en_US
dc.date.accessioned 2020-08-25T09:55:07Z
dc.date.available 2020-08-25T09:55:07Z
dc.date.issued 2019 en_US
dc.identifier.issn 1058-4838 en_US
dc.identifier.doi http://dx.doi.org/10.1093/cid/ciz715 en_US
dc.identifier.other ITG-C25A; DCS; U-TML; JIF; DOI; CPDF; PMC; Abstract; ITMPUB; DSPACE68 en_US
dc.identifier.uri http://hdl.handle.net/10390/11111
dc.description.abstract BACKGROUND: Invasive salmonellosis is a common community-acquired bacteremia in persons residing in sub-Saharan Africa. However, there is a paucity of data on severe typhoid fever and its associated acute and chronic host immune response and carriage. The Severe Typhoid Fever in Africa (SETA) program, a multicountry surveillance study, aimed to address these research gaps and contribute to the control and prevention of invasive salmonellosis. METHODS: A prospective healthcare facility-based surveillance with active screening of enteric fever and clinically suspected severe typhoid fever with complications was performed using a standardized protocol across the study sites in Burkina Faso, the Democratic Republic of Congo (DRC), Ethiopia, Ghana, Madagascar, and Nigeria. Defined inclusion criteria were used for screening of eligible patients for enrollment into the study. Enrolled patients with confirmed invasive salmonellosis by blood culture or patients with clinically suspected severe typhoid fever with perforation were eligible for clinical follow-up. Asymptomatic neighborhood controls and immediate household contacts of each case were enrolled as a comparison group to assess the level of Salmonella-specific antibodies and shedding patterns. Healthcare utilization surveys were performed to permit adjustment of incidence estimations. Postmortem questionnaires were conducted in medically underserved areas to assess death attributed to invasive Salmonella infections in selected sites. RESULTS: Research data generated through SETA aimed to address scientific knowledge gaps concerning the severe typhoid fever and mortality, long-term host immune responses, and bacterial shedding and carriage associated with natural infection by invasive salmonellae. CONCLUSIONS: SETA supports public health policy on typhoid immunization strategy in Africa. en_US
dc.language English en_US
dc.relation.uri http://www.ncbi.nlm.nih.gov/pubmed/31665779 en_US
dc.subject Typhoid fever en_US
dc.subject Salmonellosis en_US
dc.subject Bacterial diseases en_US
dc.subject Epidemiology en_US
dc.subject Africa-General en_US
dc.title The Severe Typhoid Fever in Africa program: study design and methodology to assess disease severity, host immunity, and carriage associated with invasive salmonellosis en_US
dc.type Article en_US
dc.citation.issue Suppl.6 en_US
dc.citation.jtitle Clinical Infectious Diseases en_US
dc.citation.volume 69 en_US
dc.citation.pages S422-S434 en_US
dc.citation.abbreviation Clin Infect Dis en_US


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