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The Severe Typhoid Fever in Africa program: study design and methodology to assess disease severity, host immunity, and carriage associated with invasive salmonellosis

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Show simple item record Park, S. E. en_US Toy, T. en_US Cruz Espinoza, L. M. en_US Panzner, U. en_US Mogeni, O. D. en_US Im, J. en_US Poudyal, N. en_US Pak, G. D. en_US Seo, H. en_US Chon, Y. en_US Schutt-Gerowitt, H. en_US Mogasale, V. en_US Ramani, E. en_US Dey, A. en_US Park, J. Y. en_US Kim, J. H. en_US Seo, H. J. en_US Jeon, H. J. en_US Haselbeck, A. en_US Conway, R. K. en_US Macwright, W. en_US Adu-Sarkodie, Y. en_US Owusu-Dabo, E. en_US Osei, I. en_US Owusu, M. en_US Rakotozandrindrainy, R. en_US Soura, A. B. en_US Kabore, L. P. en_US Teferi, M. en_US Okeke, I. N. en_US Kehinde, A. en_US Popoola, O. en_US Jacobs, J. en_US Lunguya Metila, O. en_US Meyer, C. G. en_US Crump, J. A. en_US Elias, S. en_US MacLennan, C. A. en_US Parry, C. M. en_US Baker, S. en_US Mintz, E. D. en_US Breiman, R. F. en_US Clemens, J. D. en_US Marks, F. en_US 2020-08-25T09:55:07Z 2020-08-25T09:55:07Z 2019 en_US
dc.identifier.issn 1058-4838 en_US
dc.identifier.doi en_US
dc.identifier.other ITG-C25A; DCS; U-TML; JIF; DOI; CPDF; PMC; Abstract; ITMPUB; DSPACE68 en_US
dc.description.abstract BACKGROUND: Invasive salmonellosis is a common community-acquired bacteremia in persons residing in sub-Saharan Africa. However, there is a paucity of data on severe typhoid fever and its associated acute and chronic host immune response and carriage. The Severe Typhoid Fever in Africa (SETA) program, a multicountry surveillance study, aimed to address these research gaps and contribute to the control and prevention of invasive salmonellosis. METHODS: A prospective healthcare facility-based surveillance with active screening of enteric fever and clinically suspected severe typhoid fever with complications was performed using a standardized protocol across the study sites in Burkina Faso, the Democratic Republic of Congo (DRC), Ethiopia, Ghana, Madagascar, and Nigeria. Defined inclusion criteria were used for screening of eligible patients for enrollment into the study. Enrolled patients with confirmed invasive salmonellosis by blood culture or patients with clinically suspected severe typhoid fever with perforation were eligible for clinical follow-up. Asymptomatic neighborhood controls and immediate household contacts of each case were enrolled as a comparison group to assess the level of Salmonella-specific antibodies and shedding patterns. Healthcare utilization surveys were performed to permit adjustment of incidence estimations. Postmortem questionnaires were conducted in medically underserved areas to assess death attributed to invasive Salmonella infections in selected sites. RESULTS: Research data generated through SETA aimed to address scientific knowledge gaps concerning the severe typhoid fever and mortality, long-term host immune responses, and bacterial shedding and carriage associated with natural infection by invasive salmonellae. CONCLUSIONS: SETA supports public health policy on typhoid immunization strategy in Africa. en_US
dc.language English en_US
dc.relation.uri en_US
dc.subject Typhoid fever en_US
dc.subject Salmonellosis en_US
dc.subject Bacterial diseases en_US
dc.subject Epidemiology en_US
dc.subject Africa-General en_US
dc.title The Severe Typhoid Fever in Africa program: study design and methodology to assess disease severity, host immunity, and carriage associated with invasive salmonellosis en_US
dc.type Article en_US
dc.citation.issue Suppl.6 en_US
dc.citation.jtitle Clinical Infectious Diseases en_US
dc.citation.volume 69 en_US
dc.citation.pages S422-S434 en_US
dc.citation.abbreviation Clin Infect Dis en_US

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