Institute of Tropical Medicine Antwerp
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Pediatric human immunodeficiency virus screening in an African district hospital

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Show simple item record De Baets, A. J. en_US Edidi, B. S. en_US Kasali, M. J. en_US Beelaert, G. en_US Schrooten, W. en_US Litzroth, A. en_US Kolsteren, P. en_US Denolf, D. en_US Fransen, K. en_US 2007-12-06T14:42:30Z 2007-12-06T14:42:30Z 2005 en_US
dc.identifier.issn 1071-412X en_US
dc.identifier.other ITG-H1B en_US
dc.identifier.other ITG-M4B en_US
dc.identifier.other ITG-C5A en_US
dc.identifier.other ITG-M6B en_US
dc.identifier.other ITG-H7A en_US
dc.identifier.other ITG-MLA en_US
dc.identifier.other HEALTH en_US
dc.identifier.other U-VOED en_US
dc.identifier.other CLINIC en_US
dc.identifier.other U-HIVCLI en_US
dc.identifier.other MICRO en_US
dc.identifier.other U-VIROL en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other MULTI en_US
dc.identifier.other ABSTRACT en_US
dc.description.abstract In order to evaluate alternative tests and strategies to simplify pediatric human immunodeficiency virus (HIV) screening at the district hospital level, a cross-sectional exploratory study was organized in the Democratic Republic of the Congo. Venous and capillary phlebotomies were performed on 941 Congolese children, aged 1 month to 12 years (153 children under 18 months and 788 children more than 18 months old). The HIV prevalence rate was 4.7%. An algorithm for children more than 18 months old, using serial rapid tests (Determine, InstantScreen, and Uni-Gold) performed on capillary blood stored in EDTA tubes, had a sensitivity of 100.0% (95% confidence interval [CI], 88.9 to 100.0%) and a specificity of 100.0% (95% CI, 99.5 to 100.0%). The results of this study suggest that the ultrasensitive p24 antigen assay may be performed on capillary plasma stored on filter paper (sensitivity and specificity, 100.0%; n=87) instead of venous plasma (sensitivity, 92.3%; specificity, 100.0%; n=150). The use of glucolets (instruments used to perform capillary phlebotomies), instead of syringes and needles, may reduce procedural pain and the risk of needle stick injuries at a comparable cost. Compared to the reference, HIV could have been correctly excluded based on one rapid test for at least 90% of these children. The results of this study point towards underutilized opportunities to simplify phlebotomy and pediatric HIV screening. en_US
dc.language English en_US
dc.subject Viral diseases en_US
dc.subject HIV en_US
dc.subject AIDS en_US
dc.subject Children en_US
dc.subject Screening en_US
dc.subject Rapid diagnostic tests en_US
dc.subject Algorithms en_US
dc.subject Congo-Kinshasa en_US
dc.subject Africa, Central en_US
dc.title Pediatric human immunodeficiency virus screening in an African district hospital en_US
dc.type Article en_US
dc.citation.issue 1 en_US
dc.citation.jtitle Clinical and Diagnostic Laboratory Immunology en_US
dc.citation.volume 12 en_US
dc.citation.pages 86-92 en_US
dc.citation.jabbreviation Clin Diagn Lab Immunol en_US

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