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The induction of a type 1 immune response following a Trypanosoma brucei infection is MyD88 dependent

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dc.contributor.author Drennan, M. B. en_US
dc.contributor.author Stijlemans, B. en_US
dc.contributor.author Van den Abbeele, J. en_US
dc.contributor.author Quesniaux, V. J. en_US
dc.contributor.author Barkhuizen, M. en_US
dc.contributor.author Brombacher, F. en_US
dc.contributor.author De Baetselier, P. en_US
dc.contributor.author Ryffel, B. en_US
dc.contributor.author Magez, S. en_US
dc.date.accessioned 2007-12-06T14:33:25Z
dc.date.available 2007-12-06T14:33:25Z
dc.date.issued 2005 en_US
dc.identifier.issn 0022-1767 en_US
dc.identifier.other ITG-P3A en_US
dc.identifier.other PARAS en_US
dc.identifier.other U-ENTOM en_US
dc.identifier.other JIF en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/129
dc.description.abstract The initial host response toward the extracellular parasite Trypanosoma brucei is characterized by the early release of inflammatory mediators associated with a type 1 immune response. In this study, we show that this inflammatory response is dependent on activation of the innate immune system mediated by the adaptor molecule MyD88. In the present study, MyD88-deficient macrophages are nonresponsive toward both soluble variant-specific surface glycoprotein (VSG), as well as membrane-bound VSG purified from T. brucei. Infection of MyD88-deficient mice with either clonal or nonclonal stocks of T. brucei resulted in elevated levels of parasitemia. This was accompanied by reduced plasma IFN-gamma and TNF levels during the initial stage of infection, followed by moderately lower VSG-specific IgG2a Ab titers during the chronic stages of infection. Analysis of several TLR-deficient mice revealed a partial requirement for TLR9 in the production of IFN-gamma and VSG-specific IgG2a Ab levels during T. brucei infections. These results implicate the mammalian TLR family and MyD88 signaling in the innate immune recognition of T. brucei. en_US
dc.language English en_US
dc.subject Protozoology en_US
dc.subject Trypanosoma brucei en_US
dc.subject Immune response en_US
dc.subject Innate immunity en_US
dc.subject MyD88 en_US
dc.title The induction of a type 1 immune response following a Trypanosoma brucei infection is MyD88 dependent en_US
dc.type Article en_US
dc.citation.jtitle Journal of Immunology en_US
dc.citation.volume 175 en_US
dc.citation.pages 2501-2509 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/16081822
dc.citation.jabbreviation J Immunol en_US


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