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Genomic rearrangements in trypanosomatids: an alternative to the "one gene" evolutionary hypotheses?

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Show simple item record Dujardin, J. C. en_US Henriksson, J. en_US Victoir, K. en_US Brisse, S. en_US Gamboa, D. en_US Arevalo, J. en_US Le Ray, D. en_US 2007-12-06T14:33:26Z 2007-12-06T14:33:26Z 2000 en_US
dc.identifier.issn 0074-0276 en_US
dc.identifier.other ITG-P1A en_US
dc.identifier.other ITG-P3B en_US
dc.identifier.other ITG-P5B en_US
dc.identifier.other ITG-PLA en_US
dc.identifier.other PARAS en_US
dc.identifier.other U-PROTO en_US
dc.identifier.other JIF en_US
dc.identifier.other FTA en_US
dc.identifier.other ABSTRACT en_US
dc.description.abstract Most molecular trees of trypanosomatids are based on point mutations within DNA sequences. In contrast, there are very few evolutionary studies considering DNA (re) arrangement as genetic characters. Waiting for the completion of the various parasite genome projects, first information may already be obtained from chromosome size-polymorphism, using the appropriate algorithms for data processing. Three illustrative models are presented here. First, the case of Leishmania (Viannia) braziliensis/L. (V.) peruviana is described. Thanks to a fast evolution rate (due essentially to amplification/deletion of tandemly repeated genes), molecular karyotyping seems particularly appropriate for studying recent evolutionary divergence, including eco-geographical diversification. Secondly, karyotype evolution is considered at the level of whole genus Leishmania. Despite the fast chromosome evolution rate, there is qualitative congruence with MLEE- and RAPD-based evolutionary hypotheses. Significant differences may be observed between major lineages, likely corresponding to major and less frequent rearrangements (fusion/fission, translocation). Thirdly, comparison is made with Trypanosoma cruzi. Again congruence is observed with other hypotheses and major lineages are delineated by significant chromosome rearrangements. The level of karyotype polymorphism within that "species" is similar to the one observed in "genus" Leishmania. The relativity of the species concept among these two groups of parasites is discussed. en_US
dc.language English en_US
dc.publisher Instituto Oswaldo Cruz pt
dc.subject Protozoology en_US
dc.subject Leishmania en_US
dc.subject Trypanosoma cruzi en_US
dc.subject Chromosomes en_US
dc.subject Evolution en_US
dc.title Genomic rearrangements in trypanosomatids: an alternative to the "one gene" evolutionary hypotheses? en_US
dc.type Article en_US
dc.citation.jtitle Memorias do Instituto Oswaldo Cruz pt
dc.citation.volume 95 en_US
dc.citation.pages 527-534 en_US Rio de Janeiro pt
dc.citation.jabbreviation Mem Inst Oswaldo Cruz pt

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