Institute of Tropical Medicine Antwerp
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Selenium and iodine supplementation of rural Tibetan children affected by Kashin-beck osteoarthropathy

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dc.contributor.author Moreno-Reyes, R. en_US
dc.contributor.author Mathieu, F. en_US
dc.contributor.author Boelaert, M. en_US
dc.contributor.author Begaux, F. en_US
dc.contributor.author Suetens, C. en_US
dc.contributor.author Rivera, M. T. en_US
dc.contributor.author Nève, J. en_US
dc.contributor.author Perlmutter, N. en_US
dc.contributor.author Vanderpas, J. en_US
dc.date.accessioned 2007-12-06T14:43:17Z
dc.date.available 2007-12-06T14:43:17Z
dc.date.issued 2003 en_US
dc.identifier.issn 0002-9165 en_US
dc.identifier.other ITG-H3A en_US
dc.identifier.other HEALTH en_US
dc.identifier.other U-EPID en_US
dc.identifier.other JIF en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/1371
dc.description.abstract BACKGROUND: Kashin-Beck disease is an osteoarthropathy endemic in selenium- and iodine-deficient areas around Lhasa, Tibet. OBJECTIVE: We assessed the efficacy of selenium supplementation on disease progression. DESIGN: A double-blind, randomized controlled trial of selenium supplementation was carried out in 324 children aged 5-15 y who had Kashin-Beck disease. Two hundred eighty children received iodized oil before being randomly assigned to receive selenium or placebo, and a control group of 44 subjects was not supplemented at all. Clinical and radiologic signs, selenium status, urinary iodine, and thyroid function were evaluated at baseline and at 12 mo. RESULTS: The frequencies of joint pain, decreased joint mobility, and radiologic abnormalities were not significantly different between the 3 groups at 12 mo. Height-for-age z scores increased significantly in the subjects who received placebo and iodine or selenium and iodine. In contrast, unsupplemented control subjects did not recover from growth retardation. Serum selenium concentrations at 12 mo were within the reference range and were significantly greater in the selenium-iodine group than in the placebo-iodine group. Serum thyroid hormone concentrations were within the reference ranges after the administration of iodine, and these values were not significantly affected by selenium supplementation. CONCLUSIONS: The results of this study do not rule out the possibility that selenium may help to prevent the occurrence of Kashin-Beck disease. However, selenium supplementation had no effect on established Kashin-Beck disease, growth, or thyroid function once iodine deficiency was corrected. These results suggest that iodine, but not selenium, deficiency should be corrected in Tibetan children with Kashin-Beck disease. en_US
dc.language English en_US
dc.subject Deficiency diseases en_US
dc.subject Selenium deficiency en_US
dc.subject Iodine deficiency en_US
dc.subject Kashin-Beck disease en_US
dc.subject Osteoarthropathy en_US
dc.subject Tibet en_US
dc.subject Asia, South en_US
dc.title Selenium and iodine supplementation of rural Tibetan children affected by Kashin-beck osteoarthropathy en_US
dc.type Article en_US
dc.citation.jtitle American Journal of Clinical Nutrition en_US
dc.citation.volume 78 en_US
dc.citation.pages 137-144 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/12816783
dc.citation.jabbreviation Am J Clin Nutr en_US


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