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Follow-up of Card Agglutination Trypanosomiasis Test (CATT) positive but apparently aparasitaemic individuals in Côte d'Ivoire: evidence for a complex and heterogeneous population

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dc.contributor.author Garcia, A. en_US
dc.contributor.author Jamonneau, V. en_US
dc.contributor.author Magnus, E. en_US
dc.contributor.author Laveissière, C. en_US
dc.contributor.author Lejon, V. en_US
dc.contributor.author N'Guessan, P. en_US
dc.contributor.author N'Dri, L. en_US
dc.contributor.author Van Meirvenne, N. en_US
dc.contributor.author Büscher, P. en_US
dc.date.accessioned 2007-12-06T14:33:30Z
dc.date.available 2007-12-06T14:33:30Z
dc.date.issued 2000 en_US
dc.identifier.issn 1360-2276 en_US
dc.identifier.doi http://dx.doi.org/10.1046/j.1365-3156.2000.00623.x
dc.identifier.other ITG-P2B en_US
dc.identifier.other ITG-P5A en_US
dc.identifier.other ITG-X8P en_US
dc.identifier.other ITG-PLA en_US
dc.identifier.other PARAS en_US
dc.identifier.other U-SEROL en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other FTB en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/148
dc.description The definitive version is available at www3.interscience.wiley.com
dc.description.abstract Summary The aetiological diagnosis of human African trypanosomiasis (HAT) is based on the detection of the parasite, but currently available parasitological tests have low sensitivity and are hampered by fluctuating parasitaemia. The identification of seropositive individuals on whom to focus parasitological examination is based on antibody detection by means of the Card Agglutination Trypanosomiasis Test (CATT/T.b.gambiense). A complicating phenomenon is the occurrence of serologically positive but parasitologically unconfirmed results (isolated CATT positivity). This work presents a two-year longitudinal serological, parasitological and molecular follow-up of CATT-positive individuals including repeated examinations of each individual, to study the evolution over time of seropositivity at both the population and the individual levels. At the population level, the rate of seropositivity decreased during the first months of the survey, and afterwards showed remarkable stability. At the individual level, the results reveal the extreme heterogeneity of this population, with subjects showing fluctuating results, others with a short transient CATT positivity, and subjects that maintain their seropositivity over time. The stability of seropositivity and the pattern of results obtained with both immunological and parasitological examinations support the view that individual factors, such as immune response to infection, might be involved in the isolated CATT positivity phenomenon. en_US
dc.language English en_US
dc.publisher Blackwell Publishing
dc.subject Protozoal diseases en_US
dc.subject Trypanosomiasis, African en_US
dc.subject Trypanosoma brucei gambiense en_US
dc.subject Laboratory diagnosis en_US
dc.subject CATT en_US
dc.subject Seropositivity en_US
dc.subject Drug sensitivity testing en_US
dc.title Follow-up of Card Agglutination Trypanosomiasis Test (CATT) positive but apparently aparasitaemic individuals in Côte d'Ivoire: evidence for a complex and heterogeneous population en_US
dc.type Article en_US
dc.citation.issue 11
dc.citation.jtitle Tropical Medicine and International Health en_US
dc.citation.volume 5 en_US
dc.citation.pages 786-793 en_US
dc.publisher.place Oxford
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/11123826
dc.citation.jabbreviation Trop Med Int Health en_US


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