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Cross-reactivity of anti-galactocerebroside autoantibodies with a Trypanosoma brucei proteolipidic epitope

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dc.contributor.author Girard, M. en_US
dc.contributor.author Bisser, S. en_US
dc.contributor.author Büscher, P. en_US
dc.contributor.author Dumas, M. en_US
dc.contributor.author Preud'homme, J. L. en_US
dc.contributor.author Jauberteau, M. O. en_US
dc.date.accessioned 2007-12-06T14:33:33Z
dc.date.available 2007-12-06T14:33:33Z
dc.date.issued 2000 en_US
dc.identifier.issn 0009-9104 en_US
dc.identifier.doi http://dx.doi.org/10.1111/j.1365-2249.2000.01166.x
dc.identifier.other ITG-P3A en_US
dc.identifier.other PARAS en_US
dc.identifier.other U-SEROL en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/160
dc.description.abstract Pathogenic mechanisms of the demyelinating encephalopathy featuring the nervous phase of human African trypanosomiasis (HAT) are largely unknown. They might include autoimmune disorders. A variety of autoantibodies is detected during the disease and we have previously evidenced anti-galactocerebroside (GalC) antibodies in the serum and cerebrospinal fluid (CSF) from patients in the nervous stage (stage II) of HAT. We now show that anti-GalC antibodies recognize an antigen located on the parasite membrane and common to different strains of trypanosomes. By using affinity chromatography with a rabbit anti-GalC antiserum, a 52-kD proteolipid was isolated from the membrane of Trypanosoma brucei (T. b.) brucei AnTat 1.9, AnTat 1. 1E, and T. b. rhodesiense Etat 1.2/R and Etat 1.2/S. Antibodies directed against this antigen were found in the CSF from patients with nervous stage HAT. These CSF also contained anti-GalC antibodies and adsorption with the proteolipid decreased anti-GalC reactivity. Immunization of mice with this antigen induced the production of antibodies which cross-reacted with GalC but no protection from experimental infection with T. b. brucei. These data support the hypothesis that anti-GalC antibodies detected in the CSF from HAT patients might be induced by molecular mimicry with a parasite antigen. en_US
dc.language English en_US
dc.subject Protozoology en_US
dc.subject Trypanosoma brucei en_US
dc.subject Serology en_US
dc.subject Autoantibodies en_US
dc.subject Epitopes en_US
dc.title Cross-reactivity of anti-galactocerebroside autoantibodies with a Trypanosoma brucei proteolipidic epitope en_US
dc.type Article en_US
dc.citation.issue 3 en_US
dc.citation.jtitle Clinical and Experimental Immunology en_US
dc.citation.volume 119 en_US
dc.citation.pages 516-522 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/10691925
dc.citation.jabbreviation Clin Exp Immunol en_US


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