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Lack of effect of chemokine receptor CCR2b gene polymorphism on HIV-1 plasma RNA viral load and immune activation among HIV-1 seropositive female sex workers in Abidjan, Côte d'Ivoire

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dc.contributor.author Adjé, C. A. en_US
dc.contributor.author Bilé, C. en_US
dc.contributor.author Kestens, L. en_US
dc.contributor.author Koblavi-Dème, S. en_US
dc.contributor.author Ghys, P. D. en_US
dc.contributor.author Maurice, C. en_US
dc.contributor.author Kalou-Bidirou, M. en_US
dc.contributor.author Ekpini, R. E. en_US
dc.contributor.author Llal, R. B. en_US
dc.contributor.author Roels, T. H. en_US
dc.contributor.author Wiktor, S. Z. en_US
dc.contributor.author Nkengasong, J. N. en_US
dc.date.accessioned 2007-12-06T14:46:20Z
dc.date.available 2007-12-06T14:46:20Z
dc.date.issued 2001 en_US
dc.identifier.other ITG-M3A en_US
dc.identifier.other MICRO en_US
dc.identifier.other U-IMMUN en_US
dc.identifier.other JIF en_US
dc.identifier.other NOT AVAILABLE en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/1651
dc.description.abstract The prevalence of the CCR2b-V64I mutation among human immunodeficiency virus (HIV)-seropositive and -seronegative female workers and the potential effect of heterozygosity of this mutation on HIV-1 plasma RNA viral load and markers of immune activation were assessed. CCR2b-V64I was detected by polymerase chain reaction, followed by restriction enzymes analysis; plasma viral load was measured by the Amplicor HIV-1 monitor assay and CD4(+) T-cell counts and markers of immune activation by standard three-color FACscan flow cytometry. Of the 260 female workers, 56 (21.5%) were heterozygous for CCR2b-V64I, and 8 (3%) were homozygous. Of the 99 HIV-seronegative female workers, 19 (19.2%) were heterozygous for the CCR2b-V64I mutation compared with 37 (23%) of the 161 HIV-seropositive FSW (P = 0.47). In a univariate analysis of viral load among HIV-seropositive FSW, no difference was noted between those heterozygous for or without the mutation; both groups had plasma viral loads of 5.0 log(10) copies/ml. After controlling for the effects of CD4(+) T-cell counts in a multivariate analysis, no significant difference was observed between the groups in viral load or in markers of immune activation. The data suggest that the presence of the CCR2b mutation has no effect on HIV-1 plasma viral load and markers of immune activation in our study population. The finding that the frequency of this mutation is similar in HIV-seropositive and -seronegative female workers suggests that its presence is not associated with increased risk of HIV infection. en_US
dc.language English en_US
dc.publisher Wiley-Liss en_US
dc.subject HIV-1 en_US
dc.subject Virology en_US
dc.subject Plasma en_US
dc.subject Viral load en_US
dc.subject Immune activation en_US
dc.subject Prostitutes en_US
dc.subject Côte d'Ivoire en_US
dc.subject Africa, West en_US
dc.title Lack of effect of chemokine receptor CCR2b gene polymorphism on HIV-1 plasma RNA viral load and immune activation among HIV-1 seropositive female sex workers in Abidjan, Côte d'Ivoire en_US
dc.type Article en_US
dc.citation.jtitle Journal of Medical Virology en_US
dc.citation.volume 64 en_US
dc.citation.pages 398-401 en_US
dc.publisher.place Wilmington en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/11468722
dc.citation.jabbreviation J Med Virol en_US


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