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Anti-tuberculosis drug resistance among new and previously treated pulmonary tuberculosis patients in Cotonou, Benin

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dc.contributor.author Affolabi, D. en_US
dc.contributor.author Adjagba, O. A. B. G. en_US
dc.contributor.author Tanimomo-Kledjo, B. en_US
dc.contributor.author Gninafon, M. en_US
dc.contributor.author Anagonou, S. Y. en_US
dc.contributor.author Portaels, F. en_US
dc.date.accessioned 2007-12-06T14:46:21Z
dc.date.available 2007-12-06T14:46:21Z
dc.date.issued 2007 en_US
dc.identifier.issn 1027-3719 en_US
dc.identifier.other ITG-MLA en_US
dc.identifier.other MICRO en_US
dc.identifier.other U-MYCOB en_US
dc.identifier.other JIF en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/1654
dc.description.abstract OBJECTIVES: To assess the current anti-tuberculosis drug resistance situation in Cotonou, at the largest anti-tuberculosis centre of Benin. METHODS: A total of 470 isolates of Mycobacterium tuberculosis complex from pulmonary tuberculosis (TB) patients were analysed: 244 from new cases and 226 from previously treated cases. Drug susceptibility testing of isolates against first-line drugs was performed using the proportion method. RESULTS: Primary multidrug resistance (MDR) depends on the patients' origin: MDR in new cases is relatively high (1.6%) when all patients are considered, but low (0.5%) and comparable to 1994 national survey results when only patients residing in Benin are considered. MDR in previously treated patients (11.1%) remains comparable to the study performed in Benin in 1994. No relation was found between human immunodeficiency virus co-infection and anti-tuberculosis drug resistance. CONCLUSION: This study shows the great importance of correct patient identification in epidemiological surveys, where results may vary according to the population(s) studied. en_US
dc.language English en_US
dc.publisher International Union Against Tuberculosis And Lung Disease
dc.subject Bacterial diseases en_US
dc.subject Tuberculosis en_US
dc.subject Mycobacterium tuberculosis en_US
dc.subject Drug sensitivity testing en_US
dc.subject First-line drugs en_US
dc.subject Drug resistance en_US
dc.subject Relapses en_US
dc.subject Benin en_US
dc.subject Africa, West en_US
dc.title Anti-tuberculosis drug resistance among new and previously treated pulmonary tuberculosis patients in Cotonou, Benin en_US
dc.type Article en_US
dc.citation.issue 11 en_US
dc.citation.jtitle International Journal of Tuberculosis and Lung Disease en_US
dc.citation.volume 11 en_US
dc.citation.pages 1221-1224 en_US
dc.publisher.place Paris
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/17958985
dc.citation.jabbreviation Int J Tuberc Lung Dis en_US


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