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Potent broad cross-neutralizing sera inhibit attachment of primary HIV-1 isolates (groups M and O) to peripheral blood mononuclear cells

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dc.contributor.author Beirnaert, E. en_US
dc.contributor.author De Zutter, S. en_US
dc.contributor.author Janssens, W. en_US
dc.contributor.author van der Groen, G. en_US
dc.date.accessioned 2007-12-06T14:46:27Z
dc.date.available 2007-12-06T14:46:27Z
dc.date.issued 2001 en_US
dc.identifier.issn 0042-6822 en_US
dc.identifier.other ITG-M1B en_US
dc.identifier.other ITG-M3A en_US
dc.identifier.other ITG-MLA en_US
dc.identifier.other MICRO en_US
dc.identifier.other U-VIROL en_US
dc.identifier.other JIF en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/1672
dc.description.abstract Gp160-directed antibody-mediated neutralization is thought to function by at least two different mechanisms that impair virus entry into the host cell: inhibition of virus attachment and inhibition of virus-cell membrane fusion. Previously, the neutralization spectra of sera derived from human immunodeficiency virus type 1 (HIV-1) infected patients were determined using 17 primary isolates belonging to HIV-1 group M (env clades A-H) and group O. The sera could be categorized as potent broad cross-neutralizing, limited cross-neutralizing, and nonneutralizing sera. The aim of this study was to examine whether the neutralizing capacity of polyclonal human sera correlates with their capacity to inhibit the attachment of infectious virions to the surface of peripheral blood mononuclear cells. A 100% correlation was found between the broad cross-neutralizing capacity and the ability to inhibit binding of primary isolates belonging to different genetic clades and groups to peripheral blood mononuclear cells. These results may indicate that broad cross-neutralizing antibodies are directed against those conserved regions on gp120 that interact with the cell receptor(s) and that those antibodies can therefore interfere with the binding of virus to the host cell. en_US
dc.language English en_US
dc.subject Virology en_US
dc.subject HIV-1 en_US
dc.subject Serology en_US
dc.subject Cross-neutralization en_US
dc.subject Inhibition en_US
dc.subject Virus attachment en_US
dc.subject Antibodies en_US
dc.title Potent broad cross-neutralizing sera inhibit attachment of primary HIV-1 isolates (groups M and O) to peripheral blood mononuclear cells en_US
dc.type Article en_US
dc.citation.jtitle Virology en_US
dc.citation.volume 281 en_US
dc.citation.pages 305-314 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/11277702
dc.citation.jabbreviation Virology en_US


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