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What is the meaning of repeated isolation of Mycobacterium africanum?

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Show simple item record Bonard, D. en_US Msellati, P. en_US Rigouts, L. en_US Combe, P. en_US Coulibaly, D. en_US Coulibaly, I. M. en_US Portaels, F. en_US 2007-12-06T14:46:29Z 2007-12-06T14:46:29Z 2000 en_US
dc.identifier.issn 1027-3719 en_US
dc.identifier.other ITG-M3A en_US
dc.identifier.other ITG-MLA en_US
dc.identifier.other MICRO en_US
dc.identifier.other U-MYCOB en_US
dc.identifier.other JIF en_US
dc.identifier.other ABSTRACT en_US
dc.description.abstract Mycobacterium africanum is a member of the tuberculosis complex, together with M. tuberculosis and M. bovis. Its morphological growth is quite different from that of M tuberculosis. It is a causative agent of the same tuberculosis disease, and its precise identification seems important only for epidemiological purposes. We report here the repetitive isolation of 17 M. africanum strains (among 321 TB complex strains) during a national primary resistance survey in C te d'Ivoire in 1995. All of the M. africanum strains were isolated in four regions located in the same geographical area. They showed biochemical heterogeneity yielding three patterns, none of which was specific to one region. Molecular analysis by RFLP for 14 strains showed identical patterns for four strains, two by two, and a clustering of 62-77% homology for eight of the 14 strains (57%). This report confirms that M. africanum is less frequent than M. tuberculosis. Its repeated isolation may reflect inter-human transmission. Biochemical similarities between strains may not always be associated with a common geographical origin. en_US
dc.language English en_US
dc.publisher International Union Against Tuberculosis And Lung Disease
dc.subject Mycobacterium africanum en_US
dc.subject Bacteriology en_US
dc.subject Identification en_US
dc.subject Epidemiology en_US
dc.subject Molecular biology en_US
dc.subject Côte d'Ivoire en_US
dc.subject Africa, West en_US
dc.title What is the meaning of repeated isolation of Mycobacterium africanum? en_US
dc.type Article en_US
dc.citation.jtitle International Journal of Tuberculosis and Lung Disease en_US
dc.citation.volume 4 en_US
dc.citation.pages 1176-1180 en_US Paris
dc.citation.jabbreviation Int J Tuberc Lung Dis en_US

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