Institute of Tropical Medicine Antwerp
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Genomic polymorphism of Leishmania infantum; a relationship with clinical pleomorphism?

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dc.contributor.author Guerbouj, S. en_US
dc.contributor.author Guizani, I. en_US
dc.contributor.author Speybroeck, N. en_US
dc.contributor.author Le Ray, D. en_US
dc.contributor.author Dujardin, J. C. en_US
dc.date.accessioned 2007-12-06T14:33:35Z
dc.date.available 2007-12-06T14:33:35Z
dc.date.issued 2001 en_US
dc.identifier.doi http://dx.doi.org/10.1016/S1567-1348(01)00008-9
dc.identifier.other ITG-P1B en_US
dc.identifier.other ITG-A3A en_US
dc.identifier.other ITG-P4A en_US
dc.identifier.other ITG-PLA en_US
dc.identifier.other PARAS en_US
dc.identifier.other U-PROTO en_US
dc.identifier.other ANIMAL en_US
dc.identifier.other U-ANIMAL en_US
dc.identifier.other DOI en_US
dc.identifier.other JIF en_US
dc.identifier.other MULTI en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/167
dc.description.abstract Leishmania infantum is the etiological agent of visceral (VL) and a cutaneous form (CL) of leishmaniasis around the Mediterranean Basin. In order to document the parasite genetic background corresponding to this clinical diversity, chromosome size polymorphism was analysed in 32 French isolates (18 CL and 14 VL) originating from the Cévennes and the Pyrénées Orientales (PO), and corresponding to zymodemes MON-1 and MON-29. Five chromosomes bearing tandemly repeated genes encoding for important antigens (gp63, PSA-2 and K39) or key metabolic functions (mini-exon and rDNA) were studied. Significant size variation (100-270 kbp) was observed for chromosomes bearing mini-exon, PSA-2 and rDNA genes, which involved variation in copy number of corresponding genes. The two other chromosomes showed smaller size-variation and did not involve dosage of gp63 and K39 genes. Chromosomal size showed correlation with geography and clinical origin: (i) chromosome 2 (mini-exon) was found to be significantly smaller in the PO; (ii) chromosomes 12 (PSA-2) and 27 (rDNA) were significantly smaller in the strictly cutaneous MON-29 isolates. Gene rearrangements and their synergistic effects on the phenotypic expression of the parasite are discussed. en_US
dc.language English en_US
dc.subject Protozoology en_US
dc.subject Leishmania infantum en_US
dc.subject Genomics en_US
dc.subject Polymorphism en_US
dc.title Genomic polymorphism of Leishmania infantum; a relationship with clinical pleomorphism? en_US
dc.type Article en_US
dc.citation.issue 1 en_US
dc.citation.jtitle Infection, Genetics and Evolution en_US
dc.citation.volume 1 en_US
dc.citation.pages 49-59 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/12798050
dc.citation.jabbreviation Infect Genet Evol en_US


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