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The epidemiology of gonorrhoea, chlamydial infection and syphilis in four African cities

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Show simple item record Buvé, A. en_US Weiss, H. A. en_US Laga, M. en_US Van Dyck, E. en_US Musonda, R. en_US Zekeng, L. en_US Kahindo, M. en_US Anagonou, S. en_US Morison, L. en_US Robinson, N. J. en_US Hayes, R. J. en_US 2007-12-06T14:46:35Z 2007-12-06T14:46:35Z 2001 en_US
dc.identifier.issn 0269-9370 en_US
dc.identifier.other ITG-M1A en_US
dc.identifier.other ITG-M3A en_US
dc.identifier.other ITG-M4A en_US
dc.identifier.other MICRO en_US
dc.identifier.other U-HIVSTD en_US
dc.identifier.other JIF en_US
dc.identifier.other ABSTRACT en_US
dc.description Not the final published version
dc.description.abstract OBJECTIVES: To compare the epidemiology of gonorrhoea, chlamydial infection and syphilis in four cities in sub-Saharan Africa; two with a high prevalence of HIV infection (Kisumu, Kenya and Ndola, Zambia), and two with a relatively low HIV prevalence (Cotonou, Benin and Yaoundé, Cameroon). DESIGN: Cross-sectional study, using standardized methods, including a standardized questionnaire and standardized laboratory tests, in four cities in sub-Saharan Africa. METHODS: In each city, a random sample of about 2000 adults aged 15-49 years was taken. Consenting men and women were interviewed about their socio-demographic characteristics and their sexual behaviour, and were tested for HIV, syphilis, herpes simplex virus type 2 (HSV-2), gonorrhoea, chlamydial infection, and (women only) Trichomonas vaginalis infection. Risk factor analyses were carried out for chlamydial infection and syphilis seroreactivity. RESULTS: The prevalence of gonorrhoea ranged between 0% in men in Kisumu and 2.7% in women in Yaoundé. Men and women in Yaoundé had the highest prevalence of chlamydial infection (5.9 and 9.4%, respectively). In the other cities, the prevalence of chlamydial infection ranged between 1.3% in women in Cotonou and 4.5% in women in Kisumu. In Ndola, the prevalence of syphilis seroreactivity was over 10% in both men and women; it was around 6% in Yaoundé, 3-4% in Kisumu, and 1-2% in Cotonou. Chlamydial infection was associated with rate of partner change for both men and women, and with young age for women. At the population level, the prevalence of chlamydial infection correlated well with reported rates of partner change. Positive syphilis serology was associated with rate of partner change and with HSV-2 infection. The latter association could be due to biological interaction between syphilis and HSV-2 or to residual confounding by sexual behaviour. At the population level, there was no correlation between prevalence of syphilis seroreactivity and reported rates of partner change. CONCLUSION: Differences in prevalence of chlamydial infection could be explained by differences in reported sexual behaviour, but the variations in prevalence of syphilis seroreactivity remained unexplained. More research is needed to better understand the epidemiology of sexually transmitted infections in Africa. en_US
dc.language English en_US
dc.publisher Lippincott, Williams & Wilkins
dc.subject Sexually transmitted diseases en_US
dc.subject STD en_US
dc.subject Bacterial diseases en_US
dc.subject Viral diseases en_US
dc.subject Gonorrhea en_US
dc.subject Chlamydia en_US
dc.subject Syphilis en_US
dc.subject Epidemiology en_US
dc.subject Prevalence en_US
dc.subject Kenya en_US
dc.subject Africa, East en_US
dc.subject Zambia en_US
dc.subject Africa, Southern en_US
dc.subject Cameroon en_US
dc.subject Africa, Central en_US
dc.subject Benin en_US
dc.subject Africa, West en_US
dc.title The epidemiology of gonorrhoea, chlamydial infection and syphilis in four African cities en_US
dc.type Article en_US
dc.citation.issue Suppl.4 en_US
dc.citation.jtitle AIDS en_US
dc.citation.volume 15 en_US
dc.citation.pages S79-S88 en_US Philadelphia
dc.contributor.corpauthor Study Group on Heterogeneity of HIV Epidemics in African Cities en_US
dc.citation.jabbreviation AIDS en_US

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