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Antimalarial efficacy of chloroquine, amodiaquine, sulfadoxine-pyrimethamine, and the combinations of amodiaquine + artesunate and sulphadoxine-pyrimethamine + artesunate in Huambo and Bi provinces, central Angola

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dc.contributor.author Guthmann, J. P. en_US
dc.contributor.author Ampuero, J. en_US
dc.contributor.author Fortes, F. en_US
dc.contributor.author Van Overmeir, C. en_US
dc.contributor.author Gaboulaud, V. en_US
dc.contributor.author Tobback, S. en_US
dc.contributor.author Dunand, J. en_US
dc.contributor.author Nilton, S. en_US
dc.contributor.author Gillet, P. en_US
dc.contributor.author Franco, J. en_US
dc.contributor.author Denoncin, A. en_US
dc.contributor.author Van Herp, M. en_US
dc.contributor.author Balkan, S. en_US
dc.contributor.author Dujardin, J. C. en_US
dc.contributor.author D'Alessandro, U. en_US
dc.contributor.author Legros, D. en_US
dc.date.accessioned 2007-12-06T14:33:36Z
dc.date.available 2007-12-06T14:33:36Z
dc.date.issued 2005 en_US
dc.identifier.issn 0035-9203 en_US
dc.identifier.doi http://dx.doi.org/10.1016/j.trstmh.2004.11.010
dc.identifier.other ITG-P4B en_US
dc.identifier.other ITG-P14A en_US
dc.identifier.other ITG-P15A en_US
dc.identifier.other PARAS en_US
dc.identifier.other U-MALAR en_US
dc.identifier.other U-PROTO en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/170 en_US
dc.description.abstract We studied three antimalarial treatments in Caala and Kuito, Angola, in 2002 and 2003. We tested chloroquine (CQ), amodiaquine (AQ) and sulfadoxine-pyrimethamine (SP) in Caala, and AQ, SP and the combinations AQ+artesunate (AQ+AS) and SP+artesunate (SP+AS) in Kuito. A total of 619 children (240 in Caala, 379 in Kuito) with uncomplicated Plasmodium falciparum malaria were followed-up for 28 days, with PCR genotyping to distinguish recrudescence from reinfection. PCR-corrected failure proportions at day 28 were very high in the CQ group (83.5%, 95% CI 74.1-90.5), high in the SP groups (Caala: 25.3%, 95% CI 16.7-35.8; Kuito: 38.8%, 95% CI 28.4-50.0), around 20% in the AQ groups (Caala: 17.3%, 95% CI 10.0-27.2; Kuito: 21.6%, 95% CI 14.3-30.6) and very low in the artemisinin-based combination groups (1.2%, 95% CI 0.0-6.4 for each combination AQ+AS and SP+AS). These results show that CQ and SP are no longer efficacious in Caala and Kuito and that the moderate efficacy of AQ is likely to be compromised in the short term if used as monotherapy. We recommend the use of AQ with AS, though this combination might not have a long useful therapeutic life because of AQ resistance. en_US
dc.language English en_US
dc.publisher Elsevier
dc.subject Protozoal diseases en_US
dc.subject Malaria en_US
dc.subject Antimalarials en_US
dc.subject First-line drugs en_US
dc.subject Chloroquine en_US
dc.subject Amodiaquine en_US
dc.subject Sulfadoxine-pyrimethamine en_US
dc.subject Artemisinin combination therapies (ACT) en_US
dc.subject Pharmacology en_US
dc.subject Cost-effectiveness en_US
dc.subject Comparative study en_US
dc.subject Angola en_US
dc.subject Africa, Southern en_US
dc.title Antimalarial efficacy of chloroquine, amodiaquine, sulfadoxine-pyrimethamine, and the combinations of amodiaquine + artesunate and sulphadoxine-pyrimethamine + artesunate in Huambo and Bi provinces, central Angola en_US
dc.type Article en_US
dc.citation.issue 7 en_US
dc.citation.jtitle Transactions of the Royal Society of Tropical Medicine and Hygiene en_US
dc.citation.volume 99 en_US
dc.citation.pages 485-492 en_US
dc.publisher.place Amsterdam
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/15876443
dc.identifier.url http://www.elsevier.com/locate/trstmh
dc.citation.jabbreviation Trans R Soc Trop Med Hyg en_US


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