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First reported case of Mycobacterium ulcerans infection from China

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dc.contributor.author Faber, W. R. en_US
dc.contributor.author Pereira Arias-Bouda, L. M. en_US
dc.contributor.author Zeegelaar, J. E. en_US
dc.contributor.author Kolk, A. H. J. en_US
dc.contributor.author Fonteyne, P. A. en_US
dc.contributor.author Toonstra, J. en_US
dc.contributor.author Portaels, F. en_US
dc.date.accessioned 2007-12-06T14:46:57Z
dc.date.available 2007-12-06T14:46:57Z
dc.date.issued 2000 en_US
dc.identifier.issn 0035-9203 en_US
dc.identifier.doi http://dx.doi.org/10.1016/S0035-9203(00)90320-1
dc.identifier.other ITG-M5A en_US
dc.identifier.other ITG-MLA en_US
dc.identifier.other MICRO en_US
dc.identifier.other U-MYCOB en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/1757
dc.description.abstract Buruli ulcers have not been previously described in China, and only once at higher latitudes on the northern hemisphere. A patient who travelled in the Shan Dong Province in the People's Republic of China developed an ulcer which was proven to be a Buruli ulcer. The clinical picture and histopathological findings from biopsy specimens are characteristic for a Buruli ulcer, and also the growth in culture (Coletsos medium) at a restricted temperature of 30 degrees C. A multiplex polymerase chain reaction (PCR) based on the amplification of the gene encoding for 16S ribosomal RNA and a nested PCR based on the Mycobacterium ulcerans specific repeated sequence 2404 were performed. These PCR investigations identified the bacteria as M. ulcerans, subspecies shinshuense. The patient was initially treated with clarithromycin and rifampicin, which was changed to ciprofloxacin and rifabutin when rifampicin resistance of the first isolate was established. There were no signs of reactivation of the disease 6 months after the end of treatment. M. ulcerans infection occurs above 30 degrees latitude on the northern hemisphere in China and is caused by M. ulcerans, subspecies shinshuense. This case appears to be cured by chemotherapy alone, in contrast to the general experience that surgical treatment is indicated. The granulomatous reaction with only fragments of acid-fast bacteria in the biopsy at the end of treatment many indicate the development of an adequate cell-mediated immune response leading to resistance to the infection. en_US
dc.language English en_US
dc.publisher Elsevier
dc.subject Bacterial diseases en_US
dc.subject Mycobacterium ulcerans en_US
dc.subject Buruli ulcer en_US
dc.subject Case reports en_US
dc.subject Diagnosis en_US
dc.subject PCR en_US
dc.subject Treatment en_US
dc.subject China en_US
dc.subject Asia, East en_US
dc.subject Far East en_US
dc.title First reported case of Mycobacterium ulcerans infection from China en_US
dc.type Article en_US
dc.citation.issue 3 en_US
dc.citation.jtitle Transactions of the Royal Society of Tropical Medicine and Hygiene en_US
dc.citation.volume 94 en_US
dc.citation.pages 277-279 en_US
dc.publisher.place Amsterdam
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/10974998
dc.identifier.url http://www.elsevier.com/locate/trstmh
dc.citation.jabbreviation Trans R Soc Trop Med Hyg en_US


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