Institute of Tropical Medicine Antwerp
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Survey of the temporal changes in HIV-1 replicative fitness in the Amsterdam cohort

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Show simple item record Gali, Y. en_US Berkhout, B. en_US Vanham, G. en_US Bakker, M. en_US Back, N. K. T. en_US Ariën, K. K. en_US 2007-12-06T14:47:00Z 2007-12-06T14:47:00Z 2007 en_US
dc.identifier.issn 0042-6822 en_US
dc.identifier.other ITG-M1B en_US
dc.identifier.other ITG-M3A en_US
dc.identifier.other ITG-MLB en_US
dc.identifier.other MICRO en_US
dc.identifier.other U-VIROL en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other ABSTRACT en_US
dc.description.abstract Changes in virulence and fitness during an epidemic are common among pathogens. Several studies have shown that HIV fitness increases within a patient during disease progression, while bottlenecks, such as sexual transmission, immune pressure and drug treatment can reduce fitness. In this study, we analyzed how these opposing forces have shaped HIV-1 fitness over time. Therefore, we compared the replicative fitness of HIV-1 isolates from newly infected untreated individuals, diagnosed for HIV-1 infection early in the AIDS epidemic in Amsterdam, the Netherlands, with more recent isolates. Twenty-five early and late HIV-1 isolates, carefully matched for seroconversion time, were competed head-to-head in a dual infection/competition assay, employing peripheral blood mononuclear cells. In contrast with previous studies, we observed a trend of increasing fitness over time in the HIV epidemic of Amsterdam. Apparently, the bottleneck, occurring with each transmission event, does not completely reset the fitness increase acquired during disease progression. en_US
dc.language English en_US
dc.subject Virology en_US
dc.subject HIV-1 en_US
dc.subject Virus replication en_US
dc.subject Viral fitness en_US
dc.subject Disease progression en_US
dc.subject Trends en_US
dc.title Survey of the temporal changes in HIV-1 replicative fitness in the Amsterdam cohort en_US
dc.type Article en_US
dc.citation.issue 1 en_US
dc.citation.jtitle Virology en_US
dc.citation.volume 364 en_US
dc.citation.pages 140-146 en_US
dc.citation.jabbreviation Virology en_US

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