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Biochemical and genetic evidence for phospholipase C activity in Mycobacterium ulcerans

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dc.contributor.author Gomez, A. en_US
dc.contributor.author Mve-Obiang, A. en_US
dc.contributor.author Vray, B. en_US
dc.contributor.author Remacle, J. en_US
dc.contributor.author Chemlal, K. en_US
dc.contributor.author Meyers, W. M. en_US
dc.contributor.author Portaels, F. en_US
dc.contributor.author Fonteyne, P. A. en_US
dc.date.accessioned 2007-12-06T14:47:05Z
dc.date.available 2007-12-06T14:47:05Z
dc.date.issued 2000 en_US
dc.identifier.issn 0019-9567 en_US
dc.identifier.other ITG-M1B en_US
dc.identifier.other ITG-M2B en_US
dc.identifier.other ITG-M5B en_US
dc.identifier.other ITG-M7A en_US
dc.identifier.other ITG-MLA en_US
dc.identifier.other MICRO en_US
dc.identifier.other U-MYCOB en_US
dc.identifier.other JIF en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/1778
dc.description.abstract This study reports the existence of phospholipase C and D enzymatic activities in Mycobacterium ulcerans cultures as determined by use of thin-layer chromatography to detect diglycerides in hydrolysates of radiolabeled phosphatidylcholine. M. ulcerans DNA sequences homologous to the genes encoding phospholipase C in Mycobacterium tuberculosis and Pseudomonas aeruginosa were identified by sequence analysis and DNA-DNA hybridization. Whether or not the phospholipase C and D enzymes of M. ulcerans plays a role in the pathogenesis of the disease needs further investigation. en_US
dc.language English en_US
dc.subject Bacterial diseases en_US
dc.subject Mycobacterium ulcerans en_US
dc.subject Phospholipase en_US
dc.subject Pathogenesis en_US
dc.title Biochemical and genetic evidence for phospholipase C activity in Mycobacterium ulcerans en_US
dc.type Article en_US
dc.citation.issue 5 en_US
dc.citation.jtitle Infection and Immunity en_US
dc.citation.volume 68 en_US
dc.citation.pages 2995-2997 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/10769001
dc.citation.jabbreviation Infect Immun en_US


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