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Pathology of Tnf-deficient mice infected with Plasmodium chabaudi adami 408XZ

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dc.contributor.author Hernandez-Valladares, M. en_US
dc.contributor.author Naessens, J. en_US
dc.contributor.author Musoke, A. J. en_US
dc.contributor.author Sekikawa, K. en_US
dc.contributor.author Rihet, P. en_US
dc.contributor.author ole-MoiYoi, O. K. en_US
dc.contributor.author Büscher, P. en_US
dc.contributor.author Iraqi, F. A. en_US
dc.date.accessioned 2007-12-06T14:33:38Z
dc.date.available 2007-12-06T14:33:38Z
dc.date.issued 2006 en_US
dc.identifier.issn 0014-4894 en_US
dc.identifier.doi http://dx.doi.org/10.1016/j.exppara.2006.04.003
dc.identifier.other ITG-P7A en_US
dc.identifier.other PARAS en_US
dc.identifier.other U-SEROL en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/177
dc.description.abstract Tumor necrosis factor alpha (Tnf) plays a pleiotropic role in murine malaria. Some investigations have correlated Tnf with hypothermia, hyperlactatemia, hypoglycemia, and a suppression of the erythropoietic response, although others have not. In this study, we have evaluated parasitemia, survival rate and several pathological features in C57BL/6JTnf(-/-) and C57BL/6JTnf(+/+) mice after infection with Plasmodium chabaudi adami 408XZ. Compared to the C57BL/6JTnf(+/+) mice, C57BL/6JTnf(-/-) mice showed increased parasitemia and decreased survival rate, whereas blood glucose, blood lactate and body weight were not significantly different. However, C57BL/6JTnf(-/-) mice suffered significantly more from severe anemia and hypothermia than C57BL/6JTnf(+/+) mice. These results suggest that Tnf is an important mediator of parasite control, but not of anemia development. We hypothesize that the high mortality observed in the Tnf knock-out mice is due to increased anemia and pathology as a direct result of increased levels of parasitemia. en_US
dc.language English en_US
dc.subject Protozoal diseases en_US
dc.subject Malaria en_US
dc.subject Murine en_US
dc.subject Mice en_US
dc.subject Plasmodium chabaudi en_US
dc.subject Disease resistance en_US
dc.subject Immune response en_US
dc.subject Tumor necrosis factor alpha en_US
dc.subject Pathology en_US
dc.subject Parasitemia en_US
dc.subject Red blood cells en_US
dc.subject Anemia en_US
dc.subject Hypothermia en_US
dc.subject Hemoglobin en_US
dc.subject Survival rate en_US
dc.title Pathology of Tnf-deficient mice infected with Plasmodium chabaudi adami 408XZ en_US
dc.type Article en_US
dc.citation.issue 4 en_US
dc.citation.jtitle Experimental Parasitology en_US
dc.citation.volume 114 en_US
dc.citation.pages 271-278 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/16716303
dc.citation.jabbreviation Exp Parasitol en_US


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