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T cell activation, apoptosis and cytokine dysregulation in the (co)pathogenesis of HIV and pulmonary tuberculosis (TB)

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dc.contributor.author Hertoghe, T. en_US
dc.contributor.author Wajja, A. en_US
dc.contributor.author Ntambi, L. en_US
dc.contributor.author Okwera, A. en_US
dc.contributor.author Aziz, M. A. en_US
dc.contributor.author Hirsch, C. en_US
dc.contributor.author Johnson, J. en_US
dc.contributor.author Toossi, Z. en_US
dc.contributor.author Mugerwa, R. en_US
dc.contributor.author Mugyenyi, P. en_US
dc.contributor.author Colebunders, R. en_US
dc.contributor.author Ellner, J. en_US
dc.contributor.author Vanham, G. en_US
dc.date.accessioned 2007-12-06T14:47:07Z
dc.date.available 2007-12-06T14:47:07Z
dc.date.issued 2000 en_US
dc.identifier.issn 0009-9104 en_US
dc.identifier.doi http://dx.doi.org/10.1111/j.1365-2249.2000.01358.x
dc.identifier.other ITG-M1B en_US
dc.identifier.other ITG-C11A en_US
dc.identifier.other ITG-MLA en_US
dc.identifier.other MICRO en_US
dc.identifier.other U-IMMUN en_US
dc.identifier.other CLINIC en_US
dc.identifier.other U-HIVCLI en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other MULTI en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/1785
dc.description.abstract Immune parameters were compared in four groups of Ugandan subjects: HIV-and HIV+ adult patients with active pulmonary TB (HIV- PTB n = 38; HIV+ PTB n = 28), patients with HIV infection only (n = 26) and PPD+ healthy controls (n = 25). Compared with healthy controls, CD4 and CD8 T cells from patients with HIV and/or PTB expressed more activation markers (HLA-DR, CD38); their CD8 T cells expressed more CD95 (pre-apoptosis) and less CD28 (co-stimulatory receptor). Peripheral blood mononuclear cells (PBMC) of patients with either HIV or PTB were impaired in interferon-gamma (IFN-gamma) production upon antigenic stimulation. PTB (with or without HIV) was characterized by monocytosis, granulocytosis, increased transforming growth factor-beta 1 production and PPD-induced apoptosis. In vivo CD4 T cell depletion, in vitro increased spontaneous CD4 T cell apoptosis and defects in IFN-gamma responses upon mitogenic stimulation were restricted to HIV+ subjects (with or without PTB). Overlapping and distinctive immune alterations, associated with PTB and HIV, might explain mutual unfavourable influences of both diseases. en_US
dc.language English en_US
dc.subject Virology en_US
dc.subject HIV en_US
dc.subject Bacterial diseases en_US
dc.subject Tuberculosis en_US
dc.subject Pathogenesis en_US
dc.subject T-cells en_US
dc.subject Apoptosis en_US
dc.subject Cytokines en_US
dc.title T cell activation, apoptosis and cytokine dysregulation in the (co)pathogenesis of HIV and pulmonary tuberculosis (TB) en_US
dc.type Article en_US
dc.citation.issue 3 en_US
dc.citation.jtitle Clinical and Experimental Immunology en_US
dc.citation.volume 122 en_US
dc.citation.pages 350-357 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/11122240
dc.citation.jabbreviation Clin Exp Immunol en_US


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