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Positive association between beta-chemokine-producing T cells and HIV type 1 viral load in HIV-infected subjects in Abidjan, Côte d'Ivoire

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dc.contributor.author Jennes, W. en_US
dc.contributor.author Sawadogo, S. en_US
dc.contributor.author Koblavi-Dème, S. en_US
dc.contributor.author Vuylsteke, B. en_US
dc.contributor.author Maurice, C. en_US
dc.contributor.author Roels, T. H. en_US
dc.contributor.author Chorba, T. en_US
dc.contributor.author Nkengasong, J. N. en_US
dc.contributor.author Kestens, L. en_US
dc.date.accessioned 2007-12-06T14:47:13Z
dc.date.available 2007-12-06T14:47:13Z
dc.date.issued 2002 en_US
dc.identifier.issn 0889-2229 en_US
dc.identifier.doi http://dx.doi.org/10.1089/08892220252781220
dc.identifier.other ITG-M1A en_US
dc.identifier.other ITG-M4A en_US
dc.identifier.other ITG-MLA en_US
dc.identifier.other MICRO en_US
dc.identifier.other U-IMMUN en_US
dc.identifier.other U-HIVSTD en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.other FTA
dc.identifier.uri http://hdl.handle.net/10390/1801
dc.description.abstract The role of beta-chemokines in controlling HIV replication in vivo is still controversial. Therefore, the association between HIV-1 plasma viral load and the capacity of CD4(+) and CD8(+) T cells to produce beta-chemokines was studied in 28 antiretroviral drug-naïve HIV-1-infected female sex workers in Abidjan, Côte d'Ivoire. Percentages of beta-chemokine-positive T cells were measured in peripheral blood mononuclear cells by flow cytometry after intracellular staining for RANTES (regulated on activation, normal T expressed and secreted), macrophage inflammatory protein (MIP)-1alpha, and MIP-1beta. HIV-1-infected subjects had higher percentages of MIP-1alpha- and MIP-1beta-positive CD4(+) and CD8(+) T cells (p < 0.02) and of RANTES-positive CD8(+) T cells (p = 0.054) than uninfected controls. Percentages of RANTES- and MIP-1beta-positive CD8(+) T cells correlated directly with HIV-1 plasma viral load (p < 0.02). Percentages of beta-chemokine-positive CD4(+) and CD8(+) T cells correlated directly with percentages of HLA-DR-positive T cells (p < 0.02) and inversely (except RANTES in CD4(+) T cells) with absolute numbers of CD4(+) T cells (p < 0.05) in peripheral blood. These data indicate that increased percentages of beta-chemokine-producing T cells in HIV-1-infected subjects correlate with disease progression and are a sign of viremia-driven chronic T cell activation. en_US
dc.language English en_US
dc.subject Virology en_US
dc.subject Immunology en_US
dc.subject HIV-1 en_US
dc.subject T-cells en_US
dc.subject Beta-chemokines en_US
dc.subject Viral load en_US
dc.subject Côte d'Ivoire en_US
dc.subject Africa, West en_US
dc.subject Africa, West en_US
dc.title Positive association between beta-chemokine-producing T cells and HIV type 1 viral load in HIV-infected subjects in Abidjan, Côte d'Ivoire en_US
dc.type Article en_US
dc.citation.issue 3 en_US
dc.citation.jtitle AIDS Research and Human Retroviruses en_US
dc.citation.volume 18 en_US
dc.citation.pages 171-177 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/11839151
dc.citation.jabbreviation AIDS Res Hum Retroviruses en_US


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