Institute of Tropical Medicine Antwerp
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Disturbed secretory capacity for macrophage inflammatory protein (MIP)-1alpha and MIP-1beta in progressive HIV infection

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Show simple item record Jennes, W. en_US Vereecken, C. en_US Fransen, K. en_US De Roo, A. en_US Kestens, L. en_US 2007-12-06T14:47:13Z 2007-12-06T14:47:13Z 2004 en_US
dc.identifier.issn 0889-2229 en_US
dc.identifier.other ITG-M1A en_US
dc.identifier.other ITG-M2B en_US
dc.identifier.other ITG-M3A en_US
dc.identifier.other ITG-C4A en_US
dc.identifier.other ITG-MLA en_US
dc.identifier.other MICRO en_US
dc.identifier.other U-IMMUN en_US
dc.identifier.other U-VIROL en_US
dc.identifier.other U-IMMUN en_US
dc.identifier.other CLINIC en_US
dc.identifier.other U-HIVCLI en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other MULTI en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.other FTA
dc.description.abstract The protective role of beta-chemokines in HIV infection and disease remains controversial. Contradictory findings have been reported possibly as the result of different beta-chemokine detection methods. To test this, peripheral blood lymphocytes from treatment-naive HIV patients, patients on highly active antiretroviral therapy (HAART), and uninfected controls were assessed for intracellular beta-chemokine levels in comparison with levels of beta-chemokine secretion in culture supernatants. HIV patients had significantly higher intracellular levels of macrophages inflammatory protein (MIP)-1 alpha and MIP-1 beta than uninfected control subjects. In contrast, MIP-1 alpha and MIP-1 beta supernatant levels were significantly lower in HIV patients than in controls. Interestingly, both intracellular and supernatant levels of RANTES (regulated on activation, normal T cell expressed and secreted) were significantly increased in HIV patients. Prolonged (> 3 years) administration of HAART in HIV patients normalized the intracellular levels of MIP-1 beta and RANTES and restored the decreased supernatant levels of MIP-1 alpha and MIP-1 beta to levels observed among controls. Significant direct correlations observed between the intracellular and the supernatant levels of beta-chemokines in controls were lost in treatment-naive (except MIP-1 beta) and HAART-treated patients (except RANTES after 3 years of HAART). These data indicate that lymphocytes of HIV patients display a disrupted capacity to secrete the beta-chemokines MIP-1 alpha and MIP-1 beta, which may constitute a mechanism of immune dysfunction in progressive HIV infection. Furthermore, we demonstrated that the detection of beta-chemokines in HIV patients by different methods may indeed result in contradictory findings. en_US
dc.language English en_US
dc.subject Viral diseases en_US
dc.subject HIV-1 en_US
dc.subject AIDS en_US
dc.subject Beta-chemokines en_US
dc.subject Lymphocytes en_US
dc.title Disturbed secretory capacity for macrophage inflammatory protein (MIP)-1alpha and MIP-1beta in progressive HIV infection en_US
dc.type Article en_US
dc.citation.issue 10 en_US
dc.citation.jtitle AIDS Research and Human Retroviruses en_US
dc.citation.volume 20 en_US
dc.citation.pages 1087-1091 en_US
dc.citation.jabbreviation AIDS Res Hum Retroviruses en_US

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