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Cutting edge: resistance to HIV-1 infection among African female sex workers is associated with inhibitory KIR in the absence of their HLA ligands

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dc.contributor.author Jennes, W. en_US
dc.contributor.author Verheyden, S. en_US
dc.contributor.author Demanet, C. en_US
dc.contributor.author Adjé-Touré, C. A. en_US
dc.contributor.author Vuylsteke, B. en_US
dc.contributor.author Nkengasong, J. N. en_US
dc.contributor.author Kestens, L. en_US
dc.date.accessioned 2007-12-06T14:47:14Z
dc.date.available 2007-12-06T14:47:14Z
dc.date.issued 2006 en_US
dc.identifier.issn 0022-1767 en_US
dc.identifier.other ITG-M1A en_US
dc.identifier.other ITG-M5A en_US
dc.identifier.other ITG-MLA en_US
dc.identifier.other MICRO en_US
dc.identifier.other U-IMMUN en_US
dc.identifier.other U-HIVSTD en_US
dc.identifier.other JIF en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.other FTC
dc.identifier.uri http://hdl.handle.net/10390/1803
dc.description.abstract NK cells are regulated in part by killer Ig-like receptors (KIR) that interact with HLA molecules on potential target cells. KIR and HLA loci are highly polymorphic and certain KIR/HLA combinations were found to protect against HIV disease progression. We show in this study that KIR/HLA interactions also influence resistance to HIV transmission. HIV-exposed but seronegative female sex workers in Abidjan, Côte d'Ivoire, frequently possessed inhibitory KIR genes in the absence of their cognate HLA genes: KIR2DL2/KIR2DL3 heterozygosity in the absence of HLA-C1 and KIR3DL1 homozygosity in the absence of HLA-Bw4. HIV-seropositive female sex workers were characterized by corresponding inhibitory KIR/HLA pairings: KIR2DL3 homozygosity together with HLA-C1 and a trend toward KIR3DL1/HLA-Bw4 homozygosity. Absence of ligands for inhibitory KIR could lower the threshold for NK cell activation. In addition, exposed seronegatives more frequently possessed AB KIR genotypes, which contain more activating KIR. The data support an important role for NK cells and KIR/HLA interactions in antiviral immunity. en_US
dc.language English en_US
dc.subject Viral diseases en_US
dc.subject HIV-1 en_US
dc.subject Prostitutes en_US
dc.subject Disease resistance en_US
dc.subject Immune response en_US
dc.subject Acquired immunity en_US
dc.subject T-cells en_US
dc.subject Natural killer cells en_US
dc.subject Receptors en_US
dc.subject HLA ligands en_US
dc.subject Côte d'Ivoire en_US
dc.subject Africa, West en_US
dc.title Cutting edge: resistance to HIV-1 infection among African female sex workers is associated with inhibitory KIR in the absence of their HLA ligands en_US
dc.type Article en_US
dc.citation.issue 10 en_US
dc.citation.jtitle Journal of Immunology en_US
dc.citation.volume 177 en_US
dc.citation.pages 6588-6592 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/17082569
dc.identifier.url http://www.jimmunol.org/content/177/10/6588.abstract
dc.citation.jabbreviation J Immunol en_US


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