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HIV-specific T helper responses and frequency of exposure among HIV-exposed seronegative female sex workers in Abidjan, Côte d'Ivoire

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Show simple item record Jennes, W. en_US Vuylsteke, B. en_US Borget, M. Y. en_US Traoré-Ettiegne, V. en_US Maurice, C. en_US Nolan, M. en_US Nkengasong, J. N. en_US Kestens, L. en_US 2007-12-06T14:47:14Z 2007-12-06T14:47:14Z 2004 en_US
dc.identifier.issn 0022-1899 en_US
dc.identifier.other ITG-M1A en_US
dc.identifier.other ITG-M2A en_US
dc.identifier.other ITG-MLA en_US
dc.identifier.other MICRO en_US
dc.identifier.other U-IMMUN en_US
dc.identifier.other U-HIVSTD en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other FTA en_US
dc.identifier.other ABSTRACT en_US
dc.description.abstract BACKGROUND: The characteristics of human immunodeficiency virus (HIV) exposure that determine the induction of HIV-specific T cells and, in particular, T helper cells are not well understood. METHODS: HIV-1 Gag- and Env-specific T helper cells were analyzed by use of an interferon (IFN)- gamma enzyme-linked immunosorbent spot (ELISPOT) assay and by use of IFN- gamma secretion flow cytometry. Responses among HIV-exposed seronegative (ESN) female sex workers (FSWs) were compared with responses among HIV-seropositive FSWs and HIV-seronegative female blood donors from Abidjan, Cote d'Ivoire. RESULTS: Low-level ELISPOT responses were detected in 8 (20%) of 40 ESN FSWs. All of 25 HIV-seropositive FSWs had high-level ELISPOT responses. HIV-specific CD4+ T cells and, occasionally, CD8+ T cells were detected by secretion flow cytometry in 3 (38%) of 8 ESN FSWs and in 4 (80%) of 5 HIV-seropositive FSWs. ESN FSWs with detectable HIV-specific T helper responses had more clients on the previous working day (P=.02) and more exposures to HIV per month (P=.02) and tended to have a lower total duration of commercial sex work. CONCLUSIONS: These findings demonstrate that the presence of HIV-specific T helper cells in ESN FSWs is associated with the frequency, rather than the duration, of exposure to HIV. The data may have important implications for the evaluation of HIV vaccine efficacy. en_US
dc.language English en_US
dc.publisher University of Chicago Press en_US
dc.subject Viral diseases en_US
dc.subject HIV en_US
dc.subject AIDS en_US
dc.subject Immune response en_US
dc.subject Exposure en_US
dc.subject T helper cells en_US
dc.subject Prostitutes en_US
dc.subject Côte d'Ivoire en_US
dc.title HIV-specific T helper responses and frequency of exposure among HIV-exposed seronegative female sex workers in Abidjan, Côte d'Ivoire en_US
dc.type Article en_US
dc.citation.issue 4 en_US
dc.citation.jtitle Journal of Infectious Diseases en_US
dc.citation.volume 189 en_US
dc.citation.pages 602-610 en_US Chicago en_US
dc.citation.jabbreviation J Infect Dis en_US

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