Institute of Tropical Medicine Antwerp
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Safety trial of the vaginal microbicide cellulose sulfate gel in HIV-positive men

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dc.contributor.author Jespers, V. en_US
dc.contributor.author Buvé, A. en_US
dc.contributor.author Van Damme, L. en_US
dc.date.accessioned 2007-12-06T14:47:15Z
dc.date.available 2007-12-06T14:47:15Z
dc.date.issued 2007 en_US
dc.identifier.issn 0148-5717 en_US
dc.identifier.doi http://dx.doi.org/10.1097/01.olq.0000253340.76118.89
dc.identifier.other ITG-M1A en_US
dc.identifier.other ITG-M2A en_US
dc.identifier.other MICRO en_US
dc.identifier.other U-HIVSTD en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/1806
dc.description.abstract OBJECTIVE: Cellulose sulfate (CS) is a promising vaginal microbicide. Because men will be exposed to the microbicide when engaging in vaginal intercourse, safety and acceptability need to be assessed in men. DESIGN: This randomized double-blind phase I study assessed the safety and acceptability of seven consecutive daily doses of CS versus KY Jelly in 36 HIV-positive men. RESULTS: No new or worsening of existing genital findings were observed during the follow-up examination. Mild genital symptoms were reported in 42% of CS users (itching, burning, tingling, testicular pain, dysuria, and warm or cold feeling) and 8% of KY Jelly users. CONCLUSION: CS gel applied to the penis was well tolerated in this HIV-positive male population. The itching and burning symptoms were not severe and can be explained by the preservative benzyl alcohol present in the CS gel. en_US
dc.language English en_US
dc.subject Viral diseases en_US
dc.subject HIV en_US
dc.subject AIDS en_US
dc.subject Control strategies en_US
dc.subject Microbicides en_US
dc.subject Cellulose sulfate en_US
dc.subject Safety en_US
dc.subject Acceptability en_US
dc.subject Men en_US
dc.subject Clinical trials en_US
dc.title Safety trial of the vaginal microbicide cellulose sulfate gel in HIV-positive men en_US
dc.type Article en_US
dc.citation.issue 7 en_US
dc.citation.jtitle Sexually Transmitted Diseases en_US
dc.citation.volume 34 en_US
dc.citation.pages 519-522 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/17297382
dc.citation.jabbreviation Sex Transm Dis en_US


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