Institute of Tropical Medicine Antwerp
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[Analysis of gag gene subtypes of HIV-1 variants isolated in Russia by comparative assessment of heteroduplex electrophoretic mobility]

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dc.contributor.author Kazennova, Y. V. en_US
dc.contributor.author Bobkov, A. F. en_US
dc.contributor.author Selimova, L. M. en_US
dc.contributor.author Khanina, T. A. en_US
dc.contributor.author Pokrovsky, V. V. en_US
dc.contributor.author Heyndrickx, L. en_US
dc.contributor.author van der Groen, G. en_US
dc.date.accessioned 2007-12-06T14:47:19Z
dc.date.available 2007-12-06T14:47:19Z
dc.date.issued 2001 en_US
dc.identifier.issn 0507-4088 en_US
dc.identifier.other ITG-M6A en_US
dc.identifier.other ITG-MLA en_US
dc.identifier.other MICRO en_US
dc.identifier.other U-VIROL en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/1817
dc.description.abstract Using heteroduplex mobility assay modified for gag gene analysis (HMA-gag), 37 HIV-1 samples previously genotyped by gag and env nucleotide sequencing were studied. It has been demonstrated that both sensitivity and specificity of HMA-gag were 100%. The gag gene region derived from 20 env subtype A HIV-1 isolates was analyzed by this method. AG recombinant, representing a circulating recombinant form of HIV-1 (AGlbNG) was found among five HIV-1 strains isolated from patients infected through heterosexual contacts in Russia. No novel recombinant forms were found among fifteen HIV-1 variants infected from drug users in 7 cities of Russia. The proposed HMA-gag method extends the potentialities of investigating the genetic variability of HIV-1 and in combination with the previously proposed method for env gene is a convenient approach to search for recombinant forms of this virus. en_US
dc.language Russian en_US
dc.subject Virology en_US
dc.subject HIV-1 en_US
dc.subject Subtypes en_US
dc.subject Russia en_US
dc.subject Europe, East en_US
dc.title [Analysis of gag gene subtypes of HIV-1 variants isolated in Russia by comparative assessment of heteroduplex electrophoretic mobility] en_US
dc.type Article en_US
dc.citation.jtitle Voprosy Virusologii ru
dc.citation.volume 46 en_US
dc.citation.pages 12-16 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/11450137
dc.citation.jabbreviation Vopr Virusol ru


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