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The local immune response in ulcerative lesions of Buruli disease

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dc.contributor.author Kiszewski, A. E. en_US
dc.contributor.author Becerril, E. en_US
dc.contributor.author Aguilar, L. D. en_US
dc.contributor.author Kader, I. T. A. en_US
dc.contributor.author Meyers, W. en_US
dc.contributor.author Portaels, F. en_US
dc.contributor.author Hernàndez Pando, R. en_US
dc.date.accessioned 2007-12-06T14:47:21Z
dc.date.available 2007-12-06T14:47:21Z
dc.date.issued 2006 en_US
dc.identifier.issn 0009-9104 en_US
dc.identifier.doi http://dx.doi.org/10.1111/j.1365-2249.2006.03020.x en_US
dc.identifier.other DOI en_US
dc.identifier.other ITG-M6A en_US
dc.identifier.other MICRO en_US
dc.identifier.other U-MYCOB en_US
dc.identifier.other JIF en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/1824
dc.description.abstract Buruli disease (BU) is a progressive necrotic and ulcerative disease of the skin and subcutaneous tissue caused by Mycobacterium ulcerans. BU is considered the third most common mycobacterial disease after tuberculosis and leprosy. Three clinical stages of the cutaneous lesions have been described in BU: pre-ulcerative, ulcerative and healed lesions. In this study we used immunohistochemistry and automated morphometry to determine the percentage of macrophages and of CD4/CD8 lymphocytes and their expression of interferon (IFN)-gamma, interleukin (IL)-10, tumour necrosis factor (TNF)-alpha and transforming growth factor (TGF)-beta. Expression of these cytokines was correlated with the inflammatory response evaluated by histopathology. All the studied BU ulcerative cases showed extensive necrosis and chronic inflammation. The most important feature was the presence or absence of granulomas co-existing with a mixed pro-inflammatory/anti-inflammatory cytokine balance. When granulomas were present significantly higher expression of IFN-gamma was seen, whereas in ulcerative lesions without granulomas there was increased expression of IL-10 and significantly higher bacillary counts. These features correlated with the chronicity of the lesions; longer-lasting lesions showed granulomas. Thus, granulomas were absent from relatively early ulcerative lesions, which contained more bacilli and little IFN-gamma, suggesting that at this stage of the disease strong suppression of the protective cellular immune response facilitates proliferation of bacilli. en_US
dc.language English en_US
dc.subject Bacterial diseases en_US
dc.subject Buruli ulcer en_US
dc.subject Mycobacterium ulcerans en_US
dc.subject Immune response en_US
dc.subject Cytokines en_US
dc.subject Granuloma en_US
dc.title The local immune response in ulcerative lesions of Buruli disease en_US
dc.type Article en_US
dc.citation.issue 3 en_US
dc.citation.jtitle Clinical and Experimental Immunology en_US
dc.citation.volume 143 en_US
dc.citation.pages 445-451 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/16487243
dc.citation.jabbreviation Clin Exp Immunol en_US


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