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Differences in HIV-2 plasma viral load and immune activation in HIV-1 and HIV-2 dually infected persons and those infected with HIV-2 only in Abidjan, Côte d'Ivoire

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dc.contributor.author Koblavi-Dème, S. en_US
dc.contributor.author Kestens, L. en_US
dc.contributor.author Hanson, D. en_US
dc.contributor.author Otten, R. A. en_US
dc.contributor.author Borget, M. Y. en_US
dc.contributor.author Bilé, C. en_US
dc.contributor.author Wiktor, S. Z. en_US
dc.contributor.author Roels, T. H. en_US
dc.contributor.author Chorba, T. en_US
dc.contributor.author Nkengasong, J. N. en_US
dc.date.accessioned 2007-12-06T14:47:22Z
dc.date.available 2007-12-06T14:47:22Z
dc.date.issued 2004 en_US
dc.identifier.issn 0269-9370 en_US
dc.identifier.other ITG-M2A en_US
dc.identifier.other MICRO en_US
dc.identifier.other U-IMMUN en_US
dc.identifier.other JIF en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/1825
dc.description Not the final published version
dc.description.abstract OBJECTIVE: To determine whether blood plasma levels of HIV-2 RNA viral loads and immune activation markers differ between persons infected with HIV-2 only and those dually infected with HIV-1 and HIV-2. METHODS: Between September 1996 and February 2000, we collected, analyzed and compared levels of HIV-2 RNA in plasma and immune activation markers among 52 persons infected with HIV-2 alone and 75 with confirmed dual infection. We also compared viral load and immune activation in patients who were infected with HIV-1 only and those who were dually infected. RESULTS: When we conducted a CD4 T-cell count-stratified multivariate analysis of HIV-2 viral load, controlling for difference in CD4 T-cell counts, age and sex: at < 200 x 10 CD4 T cells/l, HIV-2 viral load was 2.0 log10 copies/ml lower in dually infected patients than in HIV-2 only patients (P < 0.0001). At CD4 T-cell counts between 200 x 10 and 500 x 10/l, HIV-2 viral load was 0.3 log10 copies/ml lower in dually infected patients (P = 0.45). However, at CD4 T-cells counts > 500 x 10/l, HIV-2 viral load was 0.9 log10 copies/ml higher in dually infected patients (P < 0.0001). Dually infected persons with undetectable HIV-2 viral loads had significantly higher median levels of CD8 T cells expressing CD38 (P < 0.001) and HLA-DR (P = 0.01) than HIV-2 only infected patients. CONCLUSION: These results suggest that in dual infection, the level of HIV-2 replication depends on the immune status of the patients, with HIV-1 out-replicating HIV-2 as disease progress. en_US
dc.language English en_US
dc.publisher Lippincott, Williams & Wilkins
dc.subject Viral diseases en_US
dc.subject AIDS en_US
dc.subject HIV-2 en_US
dc.subject HIV-1 en_US
dc.subject Immune activation en_US
dc.subject RNA en_US
dc.subject Viral load en_US
dc.subject CD38 en_US
dc.subject HLA DR en_US
dc.subject Côte d'Ivoire en_US
dc.subject Africa, West en_US
dc.title Differences in HIV-2 plasma viral load and immune activation in HIV-1 and HIV-2 dually infected persons and those infected with HIV-2 only in Abidjan, Côte d'Ivoire en_US
dc.type Article en_US
dc.citation.jtitle AIDS en_US
dc.citation.volume 18 en_US
dc.citation.pages 413-419 en_US
dc.publisher.place Philadelphia
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/15090792
dc.citation.jabbreviation AIDS en_US


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