Institute of Tropical Medicine Antwerp
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Rapid alternative methods for detection of rifampicin resistance in Mycobacterium tuberculosis

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dc.contributor.author Lemus, D. en_US
dc.contributor.author Martin, A. en_US
dc.contributor.author Montoro, E. en_US
dc.contributor.author Portaels, F. en_US
dc.contributor.author Palomino, J. C. en_US
dc.date.accessioned 2007-12-06T14:47:27Z
dc.date.available 2007-12-06T14:47:27Z
dc.date.issued 2004 en_US
dc.identifier.issn 0305-7453 en_US
dc.identifier.doi http://dx.doi.org/10.1093/jac/dkh320
dc.identifier.other ITG-M2B en_US
dc.identifier.other ITG-M4A en_US
dc.identifier.other ITG-MLA en_US
dc.identifier.other MICRO en_US
dc.identifier.other U-MYCOB en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/1841
dc.description.abstract OBJECTIVE: To study the performance of three rapid low cost methods for the detection of rifampicin resistance. METHODS: A panel of 20 coded Mycobacterium tuberculosis strains was tested blindly by the low cost methods: nitrate reductase, MTT and resazurin assays, and compared with the results obtained with the gold standard methods: the proportion method on Löwenstein-Jensen medium and the BACTEC TB 460 system. We have also tested two commercial tests: MGIT and INNO LiPA Rif.TB kit. RESULTS: Complete agreement was observed among all methods. CONCLUSION: These three simple methods might become inexpensive alternative procedures for rapid detection of rifampicin resistance in low-resource countries. en_US
dc.language English en_US
dc.subject Bacterial diseases en_US
dc.subject Tuberculosis en_US
dc.subject Mycobacterium tuberculosis en_US
dc.subject Drug resistance en_US
dc.subject Rifampicin en_US
dc.subject Sensitivity testing en_US
dc.subject Resazurin en_US
dc.subject Nitrate reductase assay en_US
dc.subject Rapid tests en_US
dc.subject Laboratory techniques and procedures en_US
dc.title Rapid alternative methods for detection of rifampicin resistance in Mycobacterium tuberculosis en_US
dc.type Article en_US
dc.citation.issue 1 en_US
dc.citation.jtitle Journal of Antimicrobial Chemotherapy en_US
dc.citation.volume 54 en_US
dc.citation.pages 130-133 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/15190018
dc.citation.jabbreviation J Antimicrob Chemother en_US


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